Global InformationSucA RNA motif information
 | This article relies excessively on references to primary sources. (November 2021) |
| SucA RNA motif | |
|---|---|
 Predicted secondary structure and sequence conservation of sucA | |
| Identifiers | |
| Symbol | sucA |
| Rfam | RF01070 |
| Other data | |
| RNA type | Cis-reg |
| Domain(s) | Bacteria |
| SO | SO:0005836 |
| PDB structures | PDBe |
The sucA RNA motif is a conserved RNA structure found in bacteria of the order Burkholderiales.[1] RNAs within this motif are always found in the presumed 5' UTR of sucA genes. sucA encodes a subunit of an enzyme that participates in the citric acid cycle by synthesizing succinyl-CoA from 2-oxoglutarate. A part of the conserved structure overlaps predicted Shine-Dalgarno sequences (involved in ribosome binding) of the downstream sucA genes. Because of the RNA motif's consistent gene association and a possible mechanism for sequestering the ribosome binding site, it was proposed that the sucA RNA motif corresponds to a cis-regulatory element. Its relatively complex secondary structure could indicate that it is a riboswitch. However, the function of this RNA motif remains unknown.
- ^ Weinberg Z, Barrick JE, Yao Z, et al. (2007). "Identification of 22 candidate structured RNAs in bacteria using the CMfinder comparative genomics pipeline". Nucleic Acids Res. 35 (14): 4809–4819. doi:10.1093/nar/gkm487. PMC 1950547. PMID 17621584.