Global InformationStratum corneum chymotryptic enzyme information
| Stratum corneum chymotryptic enzyme | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.21.117 | ||||||||
| CAS no. | 155215-90-0 | ||||||||
| Databases | |||||||||
| IntEnz | IntEnz view | ||||||||
| BRENDA | BRENDA entry | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | KEGG entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| PRIAM | profile | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Stratum corneum chymotryptic enzyme (EC 3.4.21.117, kallikrein 7, SCCE, KLK7, PRSS6, hK7) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Cleavage of proteins with aromatic side chains in the P1 position
This enzyme has wide substrate specificity.
- ^ Skytt A, Strömqvist M, Egelrud T (June 1995). "Primary substrate specificity of recombinant human stratum corneum chymotryptic enzyme". Biochemical and Biophysical Research Communications. 211 (2): 586–9. doi:10.1006/bbrc.1995.1853. PMID 7794273.
- ^ Egelrud T (August 1993). "Purification and preliminary characterization of stratum corneum chymotryptic enzyme: a proteinase that may be involved in desquamation". The Journal of Investigative Dermatology. 101 (2): 200–4. doi:10.1111/1523-1747.ep12363804. PMID 8393902.
- ^ Hansson L, Strömqvist M, Bäckman A, Wallbrandt P, Carlstein A, Egelrud T (July 1994). "Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase". The Journal of Biological Chemistry. 269 (30): 19420–6. PMID 8034709.
- ^ Yousef GM, Scorilas A, Magklara A, Soosaipillai A, Diamandis EP (August 2000). "The KLK7 (PRSS6) gene, encoding for the stratum corneum chymotryptic enzyme is a new member of the human kallikrein gene family - genomic characterization, mapping, tissue expression and hormonal regulation". Gene. 254 (1–2): 119–28. doi:10.1016/S0378-1119(00)00280-8. PMID 10974542.
- ^ Vasilopoulos Y, Cork MJ, Murphy R, Williams HC, Robinson DA, Duff GW, Ward SJ, Tazi-Ahnini R (July 2004). "Genetic association between an AACC insertion in the 3'UTR of the stratum corneum chymotryptic enzyme gene and atopic dermatitis". The Journal of Investigative Dermatology. 123 (1): 62–6. doi:10.1111/j.0022-202X.2004.22708.x. PMID 15191543.