Stanford V (usually spoken as Stanford Five), is a chemotherapy regimen (with accompanying Radiation therapy) intended as a first-line treatment for Hodgkin lymphoma. The regimen was developed in 1988, with the objective of maintaining a high remission rate while reducing the incidence of acute and long term toxicity, pulmonary damage, and sterility observed in alternative treatment regimens such as ABVD.[1] The chemical agents used are:
A mustard derivative such as cyclophosphamide, chlormethine or ifosfamide
Doxorubicin, an anti-tumor antibiotic
Vinblastine, an alkaloid cell toxin
Vincristine, another alkaloid cell toxin
Bleomycin, another anti-tumor antibiotic
Etoposide, a DNA toxin
Prednisone, a corticosteroid
Drug Regimen[2][3]
Drug
Dose
Mode
Days
Doxorubicin
25 mg/m2
IV
Days 1 and 15
Vinblastine
6 mg/m2
IV
Days 1 and 15
Chlormethine
6 mg/m2
IV
Day 1
Vincristine
1.4 mg/m2 (max 2 mg)
IV
Days 8 and 22
Bleomycin
5 units/m2
IV
Days 8 and 22
Etoposide
60 mg/m2
IV
Days 15, 16
Prednisone
40 mg/m2
PO
Q2D
The chemotherapy part of Stanford V treatment can last anywhere from 8 to 12 weeks, depending on the staging of the disease. In many cases, this is followed by radiation therapy for anywhere from 2 to 6 weeks to the affected areas of the body.
Stanford V is a more rigorously administered form of chemotherapy, with treatments roughly twice as fast as those of other Hodgkin lymphoma treatments. However, in a randomized controlled study, Stanford V was inferior to ABVD.[4] This study has been criticized for not adhering to the proper Stanford V protocol. Specifically, the radiation therapy component following chemotherapy was not properly administered in the Italian study. A retrospective study from the Memorial Sloan-Kettering Cancer Center displayed results similar to the Stanford Cancer Center's own experience. The study concluded that, "Stanford V with appropriate radiotherapy is a highly effective regimen for locally extensive and advanced HL."[5]
^Bartlett NL, Rosenberg SA, Hoppe RT, et al. (1995). "Brief chemotherapy, Stanford V, and adjuvant radiotherapy for bulky or advanced-stage Hodgkin's disease: A preliminary report". J. Clin. Oncol. 13 (5): 1080–1088. doi:10.1200/JCO.1995.13.5.1080. PMID 7537796.
^"Cancer Care Ontario". Formulary. Retrieved 2011-05-27.
^Horning, SJ; Williams J, Bartlett NL; et al. (March 2000). "Assessment of the Stanford V Regimen and Consolidative Radiotherapy for Bulky and Advanced Hodgkin's Disease: Eastern Cooperative Oncology Group Pilot Study E1492". Journal of Clinical Oncology. 18 (5): 972–980. doi:10.1200/jco.2000.18.5.972. PMID 10694546.
^Gobbi, PG; Levis, A; Chisesi, T; et al. (2005). "ABVD versus modified stanford V versus MOPPEBVCAD with optional and limited radiotherapy in intermediate- and advanced-stage Hodgkin's lymphoma: final results of a multicenter randomized trial by the Intergruppo Italiano Linfomi". J. Clin. Oncol. 23 (36): 9198–207. doi:10.1200/JCO.2005.02.907. PMID 16172458.
^Edwards-Bennett SM, Jacks LM, Moskowitz CH, Wu EJ, Zhang Z, Noy A, Portlock CS, Straus DJ, Zelenetz AD, Yahalom J (2010). "Stanford V program for locally extensive and advanced Hodgkin lymphoma: the Memorial Sloan-Kettering Cancer Center experience". Ann. Oncol. 21 (3): 574–81. doi:10.1093/annonc/mdp337. PMID 19759185.
StanfordV (usually spoken as Stanford Five), is a chemotherapy regimen (with accompanying Radiation therapy) intended as a first-line treatment for Hodgkin...
Stanford University (officially Leland Stanford Junior University) is a private research university in Stanford, California. It was founded in 1885 by...
Sir Charles Villiers Stanford (30 September 1852 – 29 March 1924) was an Anglo-Irish composer, music teacher, and conductor of the late Romantic era. Born...
The Stanford prison experiment (SPE) was a psychological experiment conducted in August 1971. It was a two-week simulation of a prison environment that...
The Stanford Graduate School of Business (also known as Stanford GSB or simply GSB) is the graduate business school of Stanford University, a private...
Amasa Leland Stanford (March 9, 1824 – June 21, 1893) was an American attorney, industrialist, philanthropist, and Republican Party politician from California...
Robert Allen Stanford (born March 24, 1950) is a convicted financial fraudster, former financier, and sponsor of professional sports. He was convicted...
The Stanford University School of Medicine is the medical school of Stanford University and is located in Stanford, California, United States. It traces...
The Stanford Encyclopedia of Philosophy (SEP) is a freely available online philosophy resource published and maintained by Stanford University, encompassing...
Stanford Law School (SLS) is the law school of Stanford University, a private research university near Palo Alto, California. Established in 1893, Stanford...
The Stanford Cardinal are the athletic teams that represent Stanford University. Stanford's program has won 135 NCAA team championships, the most of any...
Jane Elizabeth Lathrop Stanford (August 25, 1828 – February 28, 1905) was an American philanthropist and co-founder of Stanford University in 1885 (opened...
SLAC National Accelerator Laboratory, originally named the Stanford Linear Accelerator Center, is a federally funded research and development center in...
Stanford University Medical Center is a medical complex which includes Stanford Health Care and Stanford Children's Health. It is consistently ranked as...
Following is a list of notable students and alumni of Stanford University. Gene D. Block (A.B. 1970), 8th chancellor of University of California, Los Angeles...
The Stanford Tree is the Stanford Band's mascot and the unofficial mascot of Stanford University. Stanford's team name is "Cardinal", referring to the...
Stanford University Press (SUP) is the publishing house of Stanford University. It is one of the oldest academic presses in the United States and the...
The Stanford dragon is a computer graphics 3D test model created with a Cyberware 3030 Model Shop (MS) Color 3D Scanner at Stanford University. The data...
Global Information