Spirotetronate cyclase AbyU information

L-Spirotetronate Cyclase AbyU
L-Spirotetronate Cyclase AbyU
	Depiction of the spirotetronate cyclase AbyU dimer
EC no.	?

Spirotetronate cyclase AbyU is an enzyme responsible for catalyzing the Diels-Alder reaction in the abyssomicin C biosynthetic pathway.^[1] A key step in the biosynthesis of this compound catalyzed by AbyU involves intramolecular [4+2] cycloaddition—also known as the Diels-Alder reaction—to form a heterobicyclic ring system precursor consisting of tetronic acid and a cyclohexene ring that are spiro-linked.^[1]

AbyU is a natural Diels-Alderase found in the marine actinomycete Verrucosispora maris. Abyssomicin C, synthesized with the help of AbyU, is a potent inhibitor of bacterial folate metabolism. It is effective against Mycobacterium tuberculosis and multidrug resistant clinical isolates of Staphylococcus aureus.^[2]^[1] Abyu is one of very few enzymes that are able to catalyze pericyclic reactions which effectively form regioselective and stereoselective carbon-carbon bonds.^[3]

^ ^a ^b ^c Cite error: The named reference Diels-Alderase Molecule Detail was invoked but never defined (see the help page).
^ Cite error: The named reference :0 was invoked but never defined (see the help page).
^ Ohashi, Masao; Liu, Fang; Hai, Yang; Chen, Mengbin; Tang, Man-cheng; Yang, Zhongyue; Sato, Michio; Watanabe, Kenji; Houk, K. N.; Tang, Yi (September 9, 2017). "SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis". Nature. 549 (7673): 502–506. Bibcode:2017Natur.549..502O. doi:10.1038/nature23882. ISSN 0028-0836. PMC 5679075. PMID 28902839.

[Diels-Alderase_Molecule_Detail-1] Cite error: The named reference Diels-Alderase Molecule Detail was invoked but never defined (see the help page).

[:0-2] Cite error: The named reference :0 was invoked but never defined (see the help page).

[3] Ohashi, Masao; Liu, Fang; Hai, Yang; Chen, Mengbin; Tang, Man-cheng; Yang, Zhongyue; Sato, Michio; Watanabe, Kenji; Houk, K. N.; Tang, Yi (September 9, 2017). "SAM-dependent enzyme-catalysed pericyclic reactions in natural product biosynthesis". Nature. 549 (7673): 502–506. Bibcode:2017Natur.549..502O. doi:10.1038/nature23882. ISSN 0028-0836. PMC 5679075. PMID 28902839.