The Skid Row Cancer Study was a study conducted by urologist Perry Hudson on the homeless men of the Bowery, in Lower Manhattan. In the 1950s and 1960s, Hudson went to skid row, to convince men to volunteer for his study. More than 1,200 men were promised a clean bed, three free square meals a day and free medical care if they were found to have prostate cancer. Hudson's early experience with seeing patients dying at a tuberculosis hospital he was working at led him to develop an interest in prostate cancer. His discovery about the lack of information regarding treatment for the disease and medical training for rectal exams needed to diagnose the disease drove him to pursue research in prostate cancer.
At the beginning of the experiment, Hudson and his colleague selected 141 patients having symptoms and signs for urinary obstruction. However, as the experiment progressed, patients were selected randomly.[1] They were not informed that the biopsies searching for cancer had possible side effects, i.e., rectal tearing and impotence. According to Robert Aronowitz, before the biopsy, the patients underwent a physical examination including blood and urine assays, x-rays of the abdomen, massage of the prostate for cytology and intravenous pyelograms.[2] For the biopsy, a part of the prostate measuring 2.5 × 1.0 × 0.5 centimeters[3] was removed; one half was sent to a pathology laboratory to get tested while the other half was retained for permanent preparation.[4] If the results showed cancer, a perineal prostatectomy and orchiectomy was performed on the men, followed by diethylstilbestrol treatment. The homeless were targeted for these biopsies because they were painful and untested, and less vulnerable populations would not volunteer.
^Hudson, P. B.; Finkle, A. L.; Hopkins, J. A.; Sproul, E. E.; Stout, A. P. (1954-07-01). "Prostatic cancer. XI. Early prostatic cancer diagnosed by arbitrary open perineal biopsy among 300 unselected patients". Cancer. 7 (4): 690–703. doi:10.1002/1097-0142(195407)7:4<690::aid-cncr2820070410>3.0.co;2-m. ISSN 0008-543X. PMID 13172685.
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^Hudson, P. B. (1953-02-01). "Prostatic cancer. IV. Combined surgical and endocrine management of curable lesions". Surgery, Gynecology & Obstetrics. 96 (2): 233–234. ISSN 0039-6087. PMID 13015376.
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