Sholl analysis is a method of quantitative analysis commonly used in neuronal studies to characterize the morphological characteristics of an imaged neuron, first used to describe the differences in the visual and motor cortices of cats in the early 1950s.[1] Sholl was interested in comparing the morphology of different types of neurons, such as the star-shaped stellate cells and the cone-shaped pyramidal cells, and of different locations in the dendritic field of the same type of neurons, such as basal and apical processes of the pyramidal neuron. He looked at dendritic length and diameter (Sholl, p. 389, Fig. 1)[1] and also the number of cells per volume (Sholl, p. 401, The packing density of perikarya).[1]
While methods for estimating the number of cells have vastly improved since 1953 with the advent of unbiased stereology, the method Sholl used to record the number of intersections at various distances from the cell body is still in use and is actually named after Sholl. "In order to study the way in which the number of branches varies with the distance from the perikaryon, it is convenient to use a series of concentric spherical shells as co-ordinates of reference. ...... these shells have their common centre in the perikaryon" (Sholl, p. 392, The manner of dendritic branching).[1] What Sholl called the 'Concentric Shell Method' is now known as 'Sholl Analysis'. As well as the number of intersections per concentric shell, Sholl also calculated the mean diameter of the dendrites or axons within each concentric shell (Sholl, p. 396, table 2 and 3).[1] Sholl appreciated that his method is good for comparing neurons, for instance in figure 8[1] the differences in the number of dendritic intersections correlated with distance from the cell body is compared between neurons from the motor and visual cortex. Sholl also realized his method is useful to determine where and how big is the region where synapses are possible, something he called the neuron's 'connective zone'.[1]
In 1953, Sholl was working with projections of 3-D neurons into two-dimensions, but now Sholl analysis can be done on 3-D images (e.g. image stacks or 3-D montages) of neurons, making the concentric circles truly three-dimensional shells. In addition to intersections and diameter: total dendritic length, surface area, and volume of processes per shell; number of nodes, endings, varicosities and spines per shell; and branching order of the dendrites in each shell, can be included in the analysis. For modern examples of the use of Sholl analysis to analyze neurons.[2][3] Curves produced from the 'number of intersections vs. distance from the cell body data' are usually of somewhat irregular shape, and much work has been done to determine appropriate means of analyzing the results. Common methods include Linear Analysis, Semi-log Analysis and Log-Log Analysis
^ abcdefgSholl, D.A., 1953. Dendritic organization in the neurons of the visual and
motor cortices of the cat. J. Anat. 87, 387–406
^Chowdhury, T., Barbarich-Marsteller, N., Chan, T., & Aoki, C. (2013). Activity-based anorexia has differential effects on apical dendritic branching in dorsal and ventral hippocampal CA1. Brain Structure and Function, 1-11.
Shollanalysis is a method of quantitative analysis commonly used in neuronal studies to characterize the morphological characteristics of an imaged neuron...
Sholl is a surname which may refer to: Betsy Sholl, American poet Brad Sholl (born 1972), Australian rules footballer Brett Sholl (born 1971), Australian...
neuroscience databases Neuronal galvanotropism Neuroplasticity Red neuron Shollanalysis "Stepwise emergence of the neuronal gene expression program in early...
May 2019. Article discussing the disorder and its relationship to OCD. Sholl J (2010). Dirty Secret: A Daughter Comes Clean About Her Mother's Compulsive...
Pennsylvania, about 1,300 years old, has been protected by the Hoverter and Sholl Box Huckleberry Natural Area. Box huckleberry is a low shrub, growing 6...
1942: a working musician in occupied Paris, In: ``Messiaen Studies, Robert Sholl (Ed.), Cambridge University Press, 2008, ISBN 9780521839815 Nigel Simeone...
July 20, 2020. Pastine, Luis A.; Acevedo, Jorge; Siciliano, Salvatore; Sholl, Thais G. C.; de Moura, Jailson F.; Ott, Paulo H.; Aguayo-Lobo, Anelio (December...
Retrieved 8 September 2020. Collings, Tom (10 August 2020). "Opposition Analysis: Round 11". Geelong FC Media. Retrieved 8 September 2020. "Round 11 • St...
273–287. Bibcode:1985AuJPh..38..273M. doi:10.1071/PH850273. T. A. Manz; D. S. Sholl (2012). "Improved Atoms-in-Molecule Charge Partitioning Functional for Simultaneously...
analyzed the movement of the cantilevers over time and conducted radar analysis to locate and quantify the reinforcement. The data proved the contractor...
preadolescent activities into gender roles. Goy, Robert W.; Uno, Hideo; Sholl, Samuel A. (14 April 2020), "Psychological and Anatomical Consequences of...
reasons, but said she was available to work as an opposition scout and analysis based in Melbourne for Port Adelaide. However, on 27 October 2010, Port...
pioneers, rather than those of Wills, were generally overlooked. In her analysis of early football, Hibbins concludes that Thompson's journalistic ability...
Theologian. Abingdon, Oxon & New York: Routledge. ISBN 978-0-7546-6640-0. Sholl, Robert (2008). Messiaen Studies. Cambridge & New York: Cambridge University...
1021/ja111411q. PMID 21438585. Kulkarni, Ambarish R.; Sholl, David S. (18 June 2012). "Analysis of Equilibrium-Based TSA Processes for Direct Capture...
the 2006 season. In 2007 he participated in the Nine Network football analysis program Footy Classified, as well as special comments for radio station...
Court of Victoria". Canil, Jourdan (1 September 2020). "AFL responds after analysis reveals Danny Frawley had stage two CTE". afl.com.au. Retrieved 1 September...
51 (21): 7373–7382. doi:10.1021/ie300766s. ISSN 0888-5885. Keskin, Seda; Sholl, David S. (2009-01-21). "Assessment of a Metal−Organic Framework Membrane...
Smart, Gemma Lucy (2020). "Mental Health and Well-Being in Philosophy". In Sholl, Jonathan; Rattan, Suresh I. S. (eds.). Explaining Health Across the Sciences...
See: Feiveson, Harold; Sinden, Frank; and Socolow, Robert. Boundaries of Analysis: An Inquiry Into the Tocks Island Dam Controversy. (1976). Albert, Richard...
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