Senna glycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery.[1][5] The medication is taken by mouth or via the rectum.[1][6] It typically begins working in around 30 minutes when given by rectum and within twelve hours when given by mouth.[3] It is a weaker laxative than bisacodyl and castor oil.[1]
Common side effects of senna glycoside include abdominal cramps.[3] It is not recommended for long-term use, as it may result in poor bowel function or electrolyte problems.[1] While no harm has been found to result from use while breastfeeding, such use is not typically recommended.[1] It is not typically recommended in children.[1] Senna may change urine to a somewhat reddish color.[1] Senna derivatives are a type of stimulant laxative and are of the anthraquinone type.[1] While its mechanism of action is not entirely clear, senna is thought to act by increasing fluid secretion within and contraction of the large intestine.[1]
Sennosides come from the group of plants Senna.[3] In plant form, it has been used at least since the 700s AD.[7] It is on the World Health Organization's List of Essential Medicines.[8] It is available as a generic medication.[1][6] In 2021, it was the 270th most commonly prescribed medication in the United States, with more than 1million prescriptions.[9][10] In 2021, the combination with docusate was the 275th most commonly prescribed medication in the United States, with more than 800,000 prescriptions.[9][11] It is sold under a number of brand names including Ex-Lax and Senokot.[1]
^ abcdefghijklAmerican Society of Health-System Pharmacists (1 January 2008). "Senna". Drugs.com. Archived from the original on 6 September 2015. Retrieved 11 August 2015.
^ abcdNavti P (2010). Pharmacology for pharmacy and the health sciences : a patient-centred approach. Oxford: Oxford University Press. p. 337. ISBN 9780199559824. Archived from the original on 5 March 2016.
^"Senna(Powdered)". PubChem. U.S. National Library of Medicine.
^Cite error: The named reference Wald2016 was invoked but never defined (see the help page).
^ abHamilton RJ (2010). Tarascon pharmacopoeia (2010 ed.). Sudbury, Mass.: Jones and Bartlett. p. 181. ISBN 9780763777685. Archived from the original on 5 March 2016.
^Khare CP (2004). Indian Herbal Remedies Rational Western Therapy, Ayurvedic and Other Traditional Usage, Botany. Berlin, Heidelberg: Springer Berlin Heidelberg. p. 133. ISBN 9783642186592. Archived from the original on 5 March 2016.
^World Health Organization (2019). World Health Organization model list of essential medicines: 21st list 2019. Geneva: World Health Organization. hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
^ ab"The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
^"Sennosides - Drug Usage Statistics". ClinCalc. Archived from the original on 18 January 2024. Retrieved 14 January 2024.
^"Senna; Docusate - Drug Usage Statistics". ClinCalc. Archived from the original on 18 January 2024. Retrieved 14 January 2024.
Sennaglycoside, also known as sennoside or senna, is a medication used to treat constipation and empty the large intestine before surgery. The medication...
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chemistry, a glycoside /ˈɡlaɪkəsaɪd/ is a molecule in which a sugar is bound to another functional group via a glycosidic bond. Glycosides play numerous...
effects such as severe diaper rash. The active ingredients are several sennaglycosides which interact with immune cells in the colon. List of herbs with known...
species (along with Cassia senna) is cultivated for the leaves which yield the drug senna, known commonly as Sennaglycoside, which in turn is the base...
Properties Site of action: colon Onset of action: 6–10 hours Examples: senna, bisacodyl Prolonged use of stimulant laxatives can create drug dependence...
unidentified toxin, which might be an anthraquinone glycoside (also known as sennaglycosides). In the petioles (leaf stalks), the proportion of oxalic...
anthraquinones in natural extracts have been established. Sennaglycosides from the senna. Frangulin in Frangula alnus. Aloe-emodin in aloe resin. Carmine...
such as Philaris Aquatica. Anthraquinone glycosides are found in senna, rhubarb, and Aloe. The cardiac glycosides are phytochemicals from plants including...
glycosides are found in medicinal plants such as rhubarb, cascara, and Alexandrian senna. Plant-based laxatives made from such plants include senna,...
Rhamnus frangula, Aloe ferox, Rheum officinale, and Cassia senna.[citation needed] Glycosides of anthrone are also found in high amounts in rhubarb leaves...
Asunga; Chan, Betty S. (2016). "Pharmacological treatment of cardiac glycoside poisoning". British Journal of Clinical Pharmacology. 81 (3): 488–495...
Cassia roxburghii, the red cassia, Roxburgh's cassia or Ceylon senna, is a flowering plant in the family Fabaceae. The species is native to the Indian...
commonly anthraquinone containing laxatives such as senna, aloe vera, and other plant glycosides. The anthranoid laxatives pass through the gastrointestinal...
possibly contributing to a laxative effect are the hydroxyanthracene glycosides, which include cascarosides A, B, C, and D. Cascara contains approximately...
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