Global InformationSeletracetam information
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| Routes of administration | Oral[1][2] |
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| Bioavailability | >90%[1][2] |
| Elimination half-life | 8 hours[1][2] |
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| Chemical and physical data | |
| Formula | C10H14F2N2O |
| Molar mass | 216.232 g·mol−1 |
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Seletracetam (UCB 44212) is a pyrrolidone-derived[2] drug of the racetam family that is structurally related to levetiracetam (trade name Keppra).[2][3] It was under development by UCB Pharmaceuticals as a more potent and effective anticonvulsant drug to replace levetiracetam but its development has been halted.[1]
There are two main mechanisms of action for seletracetam. The first is its high-affinity stereospecific binding to synaptic vesicle glycoprotein 2A (SV2A).[2][3] Seletracetam has shown potent seizure suppression in models of acquired and genetic epilepsy,[3] and has been well tolerated by various animal models.[3] The second is its binding to N-type calcium channels and preventing influx of Ca2+ during high-voltage activation that is typical of epilepsy.[4][5][6]
While similar in structure to nootropic drugs, it is not expected to have cognitive enhancing properties.[7] Seletracetam was in Phase II clinical trials under the supervision of the U.S. Food and Drug Administration (FDA) but its production is on hold.[3]
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Bennettwas invoked but never defined (see the help page). - ^ a b c d e Pollard JR (January 2008). "Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy". Current Opinion in Investigational Drugs. 9 (1): 101–107. PMID 18183537.
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