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Selenomethionine information


Selenomethionine
Selenomethionine: chemical structure
Selenomethionine: chemical structure
Names
IUPAC name
2-Amino-4-(methylselanyl)butanoic acid
Other names
MSE
Identifiers
CAS Number
  • 3211-76-5 (L) checkY
  • 1464-42-2 (D/L) checkY
3D model (JSmol)
  • Interactive image
ChEBI
  • CHEBI:27585 checkY
ChemSpider
  • 14375 checkY
ECHA InfoCard 100.014.525 Edit this at Wikidata
PubChem CID
  • 15103
UNII
  • 964MRK2PEL (L) checkY
  • J9V40V4PKZ (D/L) checkY
CompTox Dashboard (EPA)
  • DTXSID7040609 Edit this at Wikidata
InChI
  • InChI=1S/C5H11NO2Se/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8) checkY
    Key: RJFAYQIBOAGBLC-UHFFFAOYSA-N checkY
SMILES
  • C[Se]CCC(C(=O)O)N
Properties
Chemical formula
C5H11NO2Se
Molar mass 196.106 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Infobox references

Selenomethionine (SeMet) is a naturally occurring amino acid. The L-selenomethionine enantiomer is the main form of selenium found in Brazil nuts, cereal grains, soybeans, and grassland legumes, while Se-methylselenocysteine, or its γ-glutamyl derivative, is the major form of selenium found in Astragalus, Allium, and Brassica species.[1] In vivo, selenomethionine is randomly incorporated instead of methionine. Selenomethionine is readily oxidized.[2]

Selenomethionine's antioxidant activity arises from its ability to deplete reactive oxygen species. Selenium and methionine also play separate roles in the formation and recycling of glutathione, a key endogenous antioxidant in many organisms, including humans.

  1. ^ Whanger, P. D. (2002). "Selenocompounds in plants and animals and their biological significance". Journal of the American College of Nutrition. 21 (3): 223–32. doi:10.1080/07315724.2002.10719214. PMID 12074249. S2CID 20483595.
  2. ^ Block, E.; Birringer, M.; Jiang, W.; Nakahodo, T.; Thompson, H. J.; Toscano, P. J.; Uzar, H.; Zhang, X.; Zhu, Z. (2001). "Allium chemistry: synthesis, natural occurrence, biological activity, and chemistry of Se-alk(en)ylselenocysteines and their γ-glutamyl derivatives and oxidation products". Journal of Agricultural and Food Chemistry. 49 (1): 458–70. doi:10.1021/jf001097b. PMID 11305255.

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Selenomethionine

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(the reaction catalyzed by cystathionase) also produces cysteine. Selenomethionine is the primary dietary form of selenium. PLP is needed as a cofactor...

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hydroxyproline , is synthesised from proline. Another example is selenomethionine). Non-proteinogenic amino acids that are found in proteins are formed...

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essential. For example, selenomethionine and selenocysteine are selenium-containing amino acids present in the human body. Selenomethionine participates in the...

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MSE

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anticancer studies using selenomethionine did not show any benefit against cancer; but, selenized yeast contains both selenomethionine and methylselenocysteine...

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vivo inhibitory efficacy toward human prostate cancer compared to selenomethionine or selenite (ion). It has recently been reported that methaneseleninic...

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akin to organic sulfides. Examples include dimethyl selenide and selenomethionine. Such compounds have few applications. Gallium(II) selenide Indium(III)...

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Facioscapulohumeral muscular dystrophy

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FSHD. One study found that vitamin C, vitamin E, zinc gluconate, and selenomethionine supplementation increased endurance and strength of the quadriceps...

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Molybdopterin

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selenium (thus removing the possibility of selenium in selenocysteine or selenomethionine form), a tungsten-selenium molybdopterin complex has not been definitively...

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Chalcogen

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