Secoisolariciresinol dehydrogenase (EC 1.1.1.331) is an enzyme with the systematic name (-)-secoisolariciresinol:NAD+ oxidoreductase.[1][2][3] This enzyme catalyses the following chemical reaction:
This enzyme is isolated from the plants Forsythia intermedia and Podophyllum peltatum.
^Xia ZQ, Costa MA, Pelissier HC, Davin LB, Lewis NG (April 2001). "Secoisolariciresinol dehydrogenase purification, cloning, and functional expression. Implications for human health protection". The Journal of Biological Chemistry. 276 (16): 12614–23. doi:10.1074/jbc.M008622200. PMID 11278426.
^Youn B, Moinuddin SG, Davin LB, Lewis NG, Kang C (April 2005). "Crystal structures of apo-form and binary/ternary complexes of Podophyllum secoisolariciresinol dehydrogenase, an enzyme involved in formation of health-protecting and plant defense lignans". The Journal of Biological Chemistry. 280 (13): 12917–26. doi:10.1074/jbc.M413266200. PMID 15653677.
^Moinuddin SG, Youn B, Bedgar DL, Costa MA, Helms GL, Kang C, Davin LB, Lewis NG (March 2006). "Secoisolariciresinol dehydrogenase: mode of catalysis and stereospecificity of hydride transfer in Podophyllum peltatum". Organic & Biomolecular Chemistry. 4 (5): 808–16. doi:10.1039/b516563f. PMID 16493463.
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