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Sda
structure of the sda antikinase
Identifiers
Symbol
Sda
Pfam
PF08970
InterPro
IPR015064
Available protein structures:
Pfam
structures / ECOD
PDB
RCSB PDB; PDBe; PDBj
PDBsum
structure summary
In molecular biology, the protein domain Sda is short for suppressor of dnaA or otherwise known as sporulation inhibitor A. It is found only in bacteria. This protein domain is highly important to cell survival. When starved of nutrients, the cell is under extreme stress so undergoes a series of reactions to increase the chances of survival. One method is to form endospores which can withstand a large amount of environmental pressure.[1] Sda protein domain is a checkpoint which prevents the formation of spores. The Sda domain affects cell signalling. It prevents the cell communicating the stress that it is under, which is crucial if the cell is to survive.
^Burkholder WF; Kurtser I; Grossman AD (2001). "Replication initiation proteins regulate a developmental checkpoint in Bacillus subtilis". Cell. 104 (2): 269–79. doi:10.1016/s0092-8674(01)00211-2. hdl:1721.1/83916. PMID 11207367. S2CID 15048130.
and 13 Related for: Sda protein domain information
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Romy; Cichos, Frank (2013). "Photothermal signal distribution analysis (PhoSDA)". Physical Chemistry Chemical Physics. 15 (12). Royal Society of Chemistry...
for the biosynthesis of the blood group Sda/Cad antigen: evidence for an unusual extended cytoplasmic domain". The Biochemical Journal. 373 (Pt 2): 369–79...
"Domain exchange: chimeras of Thermus aquaticus DNA polymerase, Escherichia coli DNA polymerase I and Thermotoga neapolitana DNA polymerase". Protein Engineering...
used for growth, brought into the cell by SdaC transport proteins and further broken down into pyruvate by the SdaA dehydratase. Though this pyruvate cannot...
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