SPEN information

SPEN
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1OW1, 2RT5, 4P6Q
Identifiers
Aliases	SPEN, HIAA0929, MINT, RBM15C, SHARP, spen family transcriptional repressor, RATARS
External IDs	OMIM: 613484; MGI: 1891706; HomoloGene: 124461; GeneCards: SPEN; OMA:SPEN - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	15,940,456 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	141,265,908 bp
RNA expression pattern
	Top expressed in
	ventricular zone; ; ganglionic eminence; ; optic nerve; ; popliteal artery; ; tibial arteries; ; parotid gland; ; Descending thoracic aorta; ; right hemisphere of cerebellum; ; Achilles tendon; ; ascending aorta;
	Top expressed in
	internal carotid artery; ; external carotid artery; ; Rostral migratory stream; ; granulocyte; ; ventricular zone; ; genital tubercle; ; tail of embryo; ; crypt of lieberkuhn of small intestine; ; visual cortex; ; neural layer of retina;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	DNA binding; protein binding; nucleic acid binding; RNA binding; transcription corepressor activity;
Cellular component	transcription repressor complex; extracellular exosome; nucleus; nucleoplasm;
Biological process	Notch signaling pathway; positive regulation of neurogenesis; mRNA splicing, via spliceosome; viral process; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; negative regulation of transcription by RNA polymerase II; transcription, DNA-templated;
	Sources:Amigo / QuickGO
Orthologs
	23013
	56381
	ENSG00000065526
	ENSMUSG00000040761
	Q96T58
	Q62504
	NM_015001
	NM_019763; NM_001347235
	NP_055816
	NP_001334164; NP_062737
	Wikidata
View/Edit Human	View/Edit Mouse

Msx2-interacting protein is a protein that in humans is encoded by the SPEN gene.^[5]^[6]^[7]

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000065526 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000040761 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Newberry EP, Latifi T, Towler DA (Sep 1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter". Biochemistry. 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362.
^ Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.
^ ^a ^b "Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000065526 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000040761 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10451362-5] Newberry EP, Latifi T, Towler DA (Sep 1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter". Biochemistry. 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362.

[pmid11331609-6] Shi Y, Downes M, Xie W, Kao HY, Ordentlich P, Tsai CC, Hon M, Evans RM (May 2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMC 312688. PMID 11331609.

[entrez-7] "Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila)".

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