SOGA2 information

MTCL1
Identifiers
Aliases	MTCL1, CCDC165, KIAA0802, SOGA2, microtubule crosslinking factor 1
External IDs	OMIM: 615766; MGI: 1915867; HomoloGene: 41017; GeneCards: MTCL1; OMA:MTCL1 - orthologs
Gene location (Human)
Chr.	Chromosome 18 (human)
End	8,832,778 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	66,756,745 bp
RNA expression pattern
	Top expressed in
	cerebellar cortex; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; cerebellar vermis; ; middle temporal gyrus; ; muscle layer of sigmoid colon; ; hair follicle; ; Brodmann area 23; ; primary visual cortex; ; retinal pigment epithelium;
	Top expressed in
	neural layer of retina; ; cerebellar vermis; ; lobe of cerebellum; ; trigeminal ganglion; ; retinal pigment epithelium; ; olfactory tubercle; ; spinal ganglia; ; lumbar spinal ganglion; ; primary motor cortex; ; pituitary gland;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; microtubule binding; RNA binding;
Cellular component	apical plasma membrane; plasma membrane; membrane; cytoplasm; midbody; spindle pole; cytoskeleton; lateral plasma membrane; extracellular space; apicolateral plasma membrane; microtubule bundle;
Biological process	regulation of autophagy; microtubule bundle formation; establishment or maintenance of epithelial cell apical/basal polarity; positive regulation of protein targeting to membrane;
	Sources:Amigo / QuickGO
Orthologs
	23255
	68617
	ENSG00000168502
	ENSMUSG00000052105
	Q9Y4B5
	Q3UHU5
	NM_015210
	NM_001114098; NM_172963
	NP_056025; NP_001365134; NP_001365135; NP_001365136
	NP_001107570; NP_766551
	Wikidata
View/Edit Human	View/Edit Mouse

SOGA2, also known as Suppressor of glucose autophagy associated 2 or CCDC165, is a protein that in humans is encoded by the SOGA2 gene.^[5]^[6] SOGA2 has two human paralogs, SOGA1 and SOGA3.^[7]^[8] In humans, the gene coding sequence is 151,349 base pairs long, with an mRNA of 6092 base pairs, and a protein sequence of 1586 amino acids. The SOGA2 gene is conserved in gorilla, baboon, galago, rat, mouse, cat, and more. There is distant conservation seen in organisms such as zebra finches and anoles.^[9] SOGA2 is ubiquitously expressed in humans, with especially high expression in brain (especially the cerebellum and hippocampus), colon, pituitary gland, small intestine, spinal cord, testis and fetal brain.^[10]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168502 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000052105 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Nagase T; Ishikawa K; Suyama M; Kikuno R; Miyajima N; Tanaka A; Kotani H; Nomura N; Ohara O (April 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.
^ "Entrez Gene: SOGA2".
^ "SOGA1". NCBI. Retrieved April 27, 2013.
^ "SOGA3". NCBI. Retrieved April 27, 2013.
^ "BLAST". NCBI BLAST. Retrieved April 27, 2013.
^ "GEO Profile 10132039". NCBI GEO. Retrieved April 27, 2013.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168502 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000052105 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9872452-5] Nagase T; Ishikawa K; Suyama M; Kikuno R; Miyajima N; Tanaka A; Kotani H; Nomura N; Ohara O (April 1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452.

[entrez-6] "Entrez Gene: SOGA2".

[NCBI_SOGA1-7] "SOGA1". NCBI. Retrieved April 27, 2013.

[NCBI_SOGA3-8] "SOGA3". NCBI. Retrieved April 27, 2013.

[NCBI_BLAST-9] "BLAST". NCBI BLAST. Retrieved April 27, 2013.

[Gene_Expression_Omnibus-10] "GEO Profile 10132039". NCBI GEO. Retrieved April 27, 2013.