SNX4 information

SNX4
Identifiers
Aliases	SNX4, ATG24B, sorting nexin 4
External IDs	OMIM: 605931; MGI: 1916400; HomoloGene: 36143; GeneCards: SNX4; OMA:SNX4 - orthologs
Gene location (Human)
Chr.	Chromosome 3 (human)
End	125,520,202 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	33,120,639 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; jejunal mucosa; ; Achilles tendon; ; kidney tubule; ; ganglionic eminence; ; ventricular zone; ; islet of Langerhans; ; duodenum; ; Epithelium of choroid plexus; ; tendon of biceps brachii;
	Top expressed in
	atrioventricular valve; ; left lung lobe; ; endocardial cushion; ; sciatic nerve; ; granulocyte; ; yolk sac; ; vestibular sensory epithelium; ; ureter; ; primitive streak; ; zygote;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	insulin receptor binding; leptin receptor binding; epidermal growth factor receptor binding; protein binding; phosphatidylinositol binding; transferrin receptor binding; lipid binding;
Cellular component	cytoplasm; extrinsic component of membrane; endosome; early endosome membrane; membrane; plasma membrane; SNARE complex; cytoplasmic dynein complex; protein-containing complex; early endosome;
Biological process	endocytosis; vesicle organization; endocytic recycling; protein transport; positive regulation of histamine secretion by mast cell;
	Sources:Amigo / QuickGO
Orthologs
	8723
	69150
	ENSG00000114520
	ENSMUSG00000022808
	O95219
	Q91YJ2
	NM_003794
	NM_080557
	NP_003785
	NP_542124
	Wikidata
View/Edit Human	View/Edit Mouse

Sorting nexin-4 is a protein that in humans is encoded by the SNX4 gene.^[5]^[6]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associated with the long isoform of the leptin receptor and with receptor tyrosine kinases for platelet-derived growth factor, insulin, and epidermal growth factor in cell cultures, but its function is unknown. This protein may form oligomeric complexes with family members.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
^ ^a ^b "Entrez Gene: SNX4 sorting nexin 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000114520 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000022808 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9819414-5] Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Mol Cell Biol. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.

[entrez-6] "Entrez Gene: SNX4 sorting nexin 4".

SNX4 information

and 7 Related for: SNX4 information

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