SH3GLB1 information

SH3GLB1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1X43
Identifiers
Aliases	SH3GLB1, Bif-1, PPP1R70, dJ612B15.2, CGI-61, SH3 domain containing GRB2 like endophilin B1, SH3 domain containing GRB2 like, endophilin B1
External IDs	OMIM: 609287; MGI: 1859730; HomoloGene: 9337; GeneCards: SH3GLB1; OMA:SH3GLB1 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	86,748,184 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	144,426,096 bp
RNA expression pattern
	Top expressed in
	tibialis anterior muscle; ; deltoid muscle; ; right ventricle; ; muscle of trunk; ; Skeletal muscle tissue of rectus abdominis; ; gastrocnemius muscle; ; thoracic diaphragm; ; oocyte; ; muscle of arm; ; biceps brachii;
	Top expressed in
	blood; ; seminiferous tubule; ; ankle; ; endothelial cell of lymphatic vessel; ; temporal muscle; ; digastric muscle; ; sternocleidomastoid muscle; ; triceps brachii muscle; ; medial head of gastrocnemius muscle; ; right ventricle;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	protein homodimerization activity; protein binding; identical protein binding; lipid binding; cadherin binding;
Cellular component	cytoplasm; Golgi apparatus; membrane; Golgi membrane; mitochondrial outer membrane; autophagosome membrane; midbody; mitochondrion; extracellular exosome; cytoplasmic vesicle; cytosol;
Biological process	cellular response to glucose starvation; regulation of cytokinesis; regulation of protein stability; positive regulation of autophagosome assembly; positive regulation of autophagy; positive regulation of protein targeting to mitochondrion; cellular response to amino acid starvation; receptor catabolic process; autophagy; protein complex oligomerization; membrane fission; positive regulation of protein oligomerization; positive regulation of membrane tubulation; autophagic cell death; regulation of macroautophagy; protein localization to vacuolar membrane; apoptotic process;
	Sources:Amigo / QuickGO
Orthologs
	51100
	54673
	ENSG00000097033
	ENSMUSG00000037062
	Q9Y371
	Q9JK48
	NM_001206651; NM_001206652; NM_001206653; NM_016009
NM_001282037; NM_001282042; NM_019464; NM_001379170; NM_001379171;
	NM_001379172; NM_001379173; NM_001379174
	NP_001193580; NP_001193581; NP_001193582; NP_057093
NP_001268966; NP_001268971; NP_062337; NP_001366099; NP_001366100;
	NP_001366101; NP_001366102; NP_001366103
	Wikidata
View/Edit Human	View/Edit Mouse

Endophilin-B1 is a protein that in humans is encoded by the SH3GLB1 gene.^[5]^[6]^[7] Endophilin-B1 belongs to the Bin/Amphiphysin/Rvs167 (BAR) family of proteins and plays a critical role in mitochondrial fission and fusion, as well as in autophagy and apoptosis.^[8]^[9]^[10] Loss of functional endophilin-B1 is seen in many different forms of cancer.^[11]^[12]^[13] The link between carcinogenesis and dysregulation of cell death pathways suggests that endophilin-B1 serves a critical tumor suppressor role in the cell, although the underlying mechanisms are not known.

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000097033 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037062 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (January 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–234. doi:10.1006/geno.2000.6378. PMID 11161816.
^ Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, et al. (June 2001). "Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax". The Journal of Biological Chemistry. 276 (23): 20559–20565. doi:10.1074/jbc.M101527200. PMID 11259440.
^ "Entrez Gene: SH3GLB1 SH3-domain GRB2-like endophilin B1".
^ Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, et al. (October 2007). "Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis". Nature Cell Biology. 9 (10): 1142–1151. doi:10.1038/ncb1634. PMC 2254521. PMID 17891140.
^ Karbowski M, Jeong SY, Youle RJ (September 2004). "Endophilin B1 is required for the maintenance of mitochondrial morphology". The Journal of Cell Biology. 166 (7): 1027–1039. doi:10.1083/jcb.200407046. PMC 2172012. PMID 15452144.
^ Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, et al. (November 2005). "Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis". Molecular and Cellular Biology. 25 (21): 9369–9382. doi:10.1128/MCB.25.21.9369-9382.2005. PMC 1265816. PMID 16227588.
^ Coppola D, Khalil F, Eschrich SA, Boulware D, Yeatman T, Wang HG (November 2008). "Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma". Cancer. 113 (10): 2665–2670. doi:10.1002/cncr.23892. PMC 2614910. PMID 18833585.
^ Coppola D, Oliveri C, Sayegh Z, Boulware D, Takahashi Y, Pow-Sang J, et al. (September 2008). "Bax-interacting factor-1 expression in prostate cancer". Clinical Genitourinary Cancer. 6 (2): 117–121. doi:10.3816/CGC.2008.n.018. PMC 2626142. PMID 18824435.
^ Coppola D, Helm J, Ghayouri M, Malafa MP, Wang HG (April 2011). "Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma". Pancreas. 40 (3): 433–437. doi:10.1097/MPA.0b013e318205eb03. PMC 3063470. PMID 21283040.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000097033 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037062 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11161816-5] Pierrat B, Simonen M, Cueto M, Mestan J, Ferrigno P, Heim J (January 2001). "SH3GLB, a new endophilin-related protein family featuring an SH3 domain". Genomics. 71 (2): 222–234. doi:10.1006/geno.2000.6378. PMID 11161816.

[pmid11259440-6] Cuddeback SM, Yamaguchi H, Komatsu K, Miyashita T, Yamada M, Wu C, et al. (June 2001). "Molecular cloning and characterization of Bif-1. A novel Src homology 3 domain-containing protein that associates with Bax". The Journal of Biological Chemistry. 276 (23): 20559–20565. doi:10.1074/jbc.M101527200. PMID 11259440.

[entrez-7] "Entrez Gene: SH3GLB1 SH3-domain GRB2-like endophilin B1".

[8] Takahashi Y, Coppola D, Matsushita N, Cualing HD, Sun M, Sato Y, et al. (October 2007). "Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis". Nature Cell Biology. 9 (10): 1142–1151. doi:10.1038/ncb1634. PMC 2254521. PMID 17891140.

[9] Karbowski M, Jeong SY, Youle RJ (September 2004). "Endophilin B1 is required for the maintenance of mitochondrial morphology". The Journal of Cell Biology. 166 (7): 1027–1039. doi:10.1083/jcb.200407046. PMC 2172012. PMID 15452144.

[10] Takahashi Y, Karbowski M, Yamaguchi H, Kazi A, Wu J, Sebti SM, et al. (November 2005). "Loss of Bif-1 suppresses Bax/Bak conformational change and mitochondrial apoptosis". Molecular and Cellular Biology. 25 (21): 9369–9382. doi:10.1128/MCB.25.21.9369-9382.2005. PMC 1265816. PMID 16227588.

[11] Coppola D, Khalil F, Eschrich SA, Boulware D, Yeatman T, Wang HG (November 2008). "Down-regulation of Bax-interacting factor-1 in colorectal adenocarcinoma". Cancer. 113 (10): 2665–2670. doi:10.1002/cncr.23892. PMC 2614910. PMID 18833585.

[12] Coppola D, Oliveri C, Sayegh Z, Boulware D, Takahashi Y, Pow-Sang J, et al. (September 2008). "Bax-interacting factor-1 expression in prostate cancer". Clinical Genitourinary Cancer. 6 (2): 117–121. doi:10.3816/CGC.2008.n.018. PMC 2626142. PMID 18824435.

[13] Coppola D, Helm J, Ghayouri M, Malafa MP, Wang HG (April 2011). "Down-regulation of Bax-interacting factor 1 in human pancreatic ductal adenocarcinoma". Pancreas. 40 (3): 433–437. doi:10.1097/MPA.0b013e318205eb03. PMC 3063470. PMID 21283040.

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