SFRP4 information

SFRP4
Identifiers
Aliases	SFRP4, FRP-4, FRPHE, sFRP-4, secreted frizzled related protein 4, PYL, FRZB-2
External IDs	OMIM: 606570; MGI: 892010; HomoloGene: 2267; GeneCards: SFRP4; OMA:SFRP4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	38,025,695 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	19,817,164 bp
RNA expression pattern
	Top expressed in
	right uterine tube; ; canal of the cervix; ; ectocervix; ; vena cava; ; tibial nerve; ; spinal ganglia; ; Achilles tendon; ; right ovary; ; left ovary; ; smooth muscle tissue;
	Top expressed in
	gastrula; ; ankle; ; superior surface of tongue; ; decidua; ; sciatic nerve; ; uterus; ; tibiofemoral joint; ; lumbar spinal ganglion; ; femur; ; body of femur;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	protein binding; Wnt-protein binding; G protein-coupled receptor activity; Wnt-activated receptor activity;
Cellular component	cytoplasm; extracellular region; cell surface; nucleus; extracellular space; integral component of membrane;
Biological process	cell differentiation; positive regulation of keratinocyte apoptotic process; positive regulation of receptor internalization; positive regulation of canonical Wnt signaling pathway; negative regulation of Wnt signaling pathway; phosphate ion homeostasis; Wnt signaling pathway; negative regulation of DNA-binding transcription factor activity; multicellular organism development; negative regulation of sodium-dependent phosphate transport; positive regulation of gene expression; positive regulation of apoptotic process; response to hormone; positive regulation of epidermal cell differentiation; negative regulation of cell population proliferation; regulation of BMP signaling pathway; bone morphogenesis; negative regulation of canonical Wnt signaling pathway; negative regulation of non-canonical Wnt signaling pathway; G protein-coupled receptor signaling pathway; non-canonical Wnt signaling pathway; canonical Wnt signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	6424
	20379
	ENSG00000106483
	ENSMUSG00000021319
	Q6FHJ7
	Q9Z1N6
	NM_003014
	NM_016687
	NP_003005
	NP_057896
	Wikidata
View/Edit Human	View/Edit Mouse

Secreted frizzled-related protein 4 is a protein that in humans is encoded by the SFRP4 gene.^[5]^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000106483 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000021319 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, Kocher O (April 1999). "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 79 (4): 439–447. PMID 10211996.
^ "Entrez Gene: SFRP4 secreted frizzled-related protein 4".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000106483 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000021319 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10211996-5] Abu-Jawdeh G, Comella N, Tomita Y, Brown LF, Tognazzi K, Sokol SY, Kocher O (April 1999). "Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy". Laboratory Investigation; A Journal of Technical Methods and Pathology. 79 (4): 439–447. PMID 10211996.

[entrez-6] "Entrez Gene: SFRP4 secreted frizzled-related protein 4".

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Wnt signaling pathway