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positive regulation of phosphatidylinositol 3-kinase signaling
positive regulation of insulin receptor signaling pathway
regulation of triglyceride metabolic process
negative regulation of peptidase activity
negative regulation of lipid biosynthetic process
negative regulation of endopeptidase activity
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
145264
68054
Ensembl
ENSG00000165953
ENSMUSG00000041567
UniProt
Q8IW75
Q7TMF5
RefSeq (mRNA)
NM_001304461 NM_173850 NM_001382267
NM_026535
RefSeq (protein)
NP_001291390 NP_776249 NP_001369196
NP_080811
Location (UCSC)
Chr 14: 94.49 – 94.52 Mb
Chr 12: 104 – 104.01 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Serpin A12 (OL-64, Vaspin, Visceral adipose-specific serpin, Ser A12) is a glycoprotein that is a class A member of the serine protease inhibitor (serpin) family.[5] In humans, Serpin A12 is encoded by the SERPINA12 gene.[6]
First discovered in 2005, Serpin A12 was highly expressed in white adipose tissue of Otsuka Long Evans Tokushima Fatty Rats at the same time that the rats' obesity and insulin plasma levels reached a peak, at around 30 weeks old. Eventually, it was found to be expressed in visceral and subcutaneous adipose tissue of obese humans, leading the protein to be linked with obesity, glucose metabolism, and insulin resistance.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000165953 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000041567 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Kyrou I, Mattu HS, Chatha K, Randeva HS (2017). "Fat Hormones, Adipokines". Endocrinology of the Heart in Health and Disease. pp. 167–205. doi:10.1016/B978-0-12-803111-7.00007-5. ISBN 9780128031117.
^ ab"UniProtKB - Q8IW75 (SPA12_HUMAN)". UniProt. November 1, 2020. Retrieved Nov 1, 2020.
SerpinA12 (OL-64, Vaspin, Visceral adipose-specific serpin, Ser A12) is a glycoprotein that is a class A member of the serine protease inhibitor (serpin)...
protein Z-dependent protease inhibitor (ZPI), a serine protease inhibitor (serpin). The affinity of this protein for factor Xa is increased 1000-fold by the...