SRP-dependent cotranslational protein targeting to membrane, translocation
posttranslational protein targeting to membrane, translocation
transport
regulation of molecular function
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10952
66212
Ensembl
ENSG00000106803
ENSMUSG00000053317
UniProt
P60468
Q9CQS8
RefSeq (mRNA)
NM_006808
NM_024171
RefSeq (protein)
NP_006799
NP_077133
Location (UCSC)
Chr 9: 99.22 – 99.23 Mb
Chr 4: 47.47 – 47.48 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Protein transport protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene.[5][6][7]
The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. The Sec61 complex forms a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript.[7]
^ abcGRCh38: Ensembl release 89: ENSG00000106803 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000053317 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Hartmann E, Sommer T, Prehn S, Gorlich D, Jentsch S, Rapoport TA (Mar 1994). "Evolutionary conservation of components of the protein translocation complex". Nature. 367 (6464): 654–7. Bibcode:1994Natur.367..654H. doi:10.1038/367654a0. PMID 8107851. S2CID 4323463.
^Greenfield JJ, High S (Aug 1999). "The Sec61 complex is located in both the ER and the ER-Golgi intermediate compartment". J Cell Sci. 112 (10): 1477–86. doi:10.1242/jcs.112.10.1477. PMID 10212142.
protein Sec61 subunit beta is a protein that in humans is encoded by the SEC61B gene. The Sec61 complex is the central component of the protein translocation...
ATPase is yet to be identified. Human proteins: SecY: SEC61A1, SEC61A2 SecG: SEC61B SecE: SEC61G Budding yeast have two such homologous complexes; the essential...