SDPR information

CAVIN2
Identifiers
Aliases	CAVIN2, PS-p68, SDR, cavin-2, SDPR, serum deprivation response, caveolae associated protein 2
External IDs	OMIM: 606728 MGI: 99513 HomoloGene: 3422 GeneCards: CAVIN2
Gene location (Human)
Chr.	Chromosome 2 (human)
End	191,847,088 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	51,342,119 bp
RNA expression pattern
	Top expressed in
	monocyte; ; lower lobe of lung; ; right lung; ; upper lobe of lung; ; superficial temporal artery; ; upper lobe of left lung; ; parietal pleura; ; abdominal fat; ; gallbladder; ; pericardium;
	Top expressed in
	right lung; ; right lung lobe; ; left lung; ; left lung lobe; ; atrioventricular valve; ; atrium; ; white adipose tissue; ; carotid body; ; subcutaneous adipose tissue; ; brown adipose tissue;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	phosphatidylserine binding; protein binding; phospholipid binding; protein kinase C binding; lipid binding;
Cellular component	cytoplasm; membrane raft; cytosol; membrane; caveola; nucleoplasm; plasma membrane; actin cytoskeleton;
Biological process	plasma membrane tubulation;
	Sources:Amigo / QuickGO
Orthologs
	8436
	20324
	ENSG00000168497
	ENSMUSG00000045954
	O95810
	Q63918
	NM_004657
	NM_138741
	NP_004648
	NP_620080
	Wikidata
View/Edit Human	View/Edit Mouse

Cavin-2 or Serum deprivation-response protein (SDPR) is a protein that in humans is encoded by the SDPR gene.^[5]^[6]^[7] Cavin-2 is highly expressed in a variety of human endothelial cells.^[8]

This gene has a calcium-independent phospholipid-binding protein whose expression increases in serum-starved cells. This protein has also been shown to be a substrate for protein kinase C (PKC) phosphorylation.^[7]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000168497 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045954 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Gustincich S, Vatta P, Goruppi S, Wolf M, Saccone S, Della Valle G, et al. (April 1999). "The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein". Genomics. 57 (1): 120–9. doi:10.1006/geno.1998.5733. PMID 10191091.
^ Gustincich S, Schneider C (September 1993). "Serum deprivation response gene is induced by serum starvation but not by contact inhibition". Cell Growth & Differentiation. 4 (9): 753–60. PMID 8241023.
^ ^a ^b "Entrez Gene: SDPR serum deprivation response (phosphatidylserine binding protein)".
^ Boopathy GT, Kulkarni M, Ho SY, Boey A, Chua EW, Barathi VA, et al. (October 2017). "Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis". The Journal of Biological Chemistry. 292 (43): 17760–17776. doi:10.1074/jbc.M117.794743. PMC 5663877. PMID 28912276.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000168497 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045954 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10191091-5] Gustincich S, Vatta P, Goruppi S, Wolf M, Saccone S, Della Valle G, et al. (April 1999). "The human serum deprivation response gene (SDPR) maps to 2q32-q33 and codes for a phosphatidylserine-binding protein". Genomics. 57 (1): 120–9. doi:10.1006/geno.1998.5733. PMID 10191091.

[pmid8241023-6] Gustincich S, Schneider C (September 1993). "Serum deprivation response gene is induced by serum starvation but not by contact inhibition". Cell Growth & Differentiation. 4 (9): 753–60. PMID 8241023.

[entrez-7] "Entrez Gene: SDPR serum deprivation response (phosphatidylserine binding protein)".

[Boopathy_2017-8] Boopathy GT, Kulkarni M, Ho SY, Boey A, Chua EW, Barathi VA, et al. (October 2017). "Cavin-2 regulates the activity and stability of endothelial nitric-oxide synthase (eNOS) in angiogenesis". The Journal of Biological Chemistry. 292 (43): 17760–17776. doi:10.1074/jbc.M117.794743. PMC 5663877. PMID 28912276.

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