The consensus secondary structure of RsaOG showing its pseudoknot, created in Varna.[1] Boundaries were determined by RACE mapping in Staphylococcus aureus N315.[2]
Identifiers
Symbol
RsaOG
Rfam
RF01775
Other data
RNA type
sRNA
Domain(s)
Staphylococcus
PDB structures
PDBe
RsaOG (an acronym for RNA S. aureus Orsay G)[2] is a non-coding RNA that was discovered in the pathogenic bacteria Staphylococcus aureus N315 using a large scale computational screening based on phylogenetic profiling.[3] It was first identified, but not named, in 2005.[4] RsaOG has since been identified in other strains of Staphylococcus aureus under the name of RsaI,[5] it has also been discovered in other members of the Staphylococcus genus (such as Staphylococcus carnosus) but in no other bacteria.[2]
The RsaOG gene is conserved in all Staphylococcaceae sequenced genomes, its secondary structure contains two highly conserved unpaired sequences which have the ability to form a pseudoknot.[2] Northern blot experiments show that RsaOG is expressed in several S. aureus strains.[3][5] Mapping of RsaOG ends indicates a size of 146 nucleotides in S. aureus.[5] RsaOG ncRNA is thought to have trans-acting regulatory functions, possibly on fine tuning toxin production or aiding with invasion.[2]
^Darty K, Denise A, Ponty Y (August 2009). "VARNA: Interactive drawing and editing of the RNA secondary structure". Bioinformatics. 25 (15): 1974–1975. doi:10.1093/bioinformatics/btp250. PMC 2712331. PMID 19398448.
^ abcdeMarchais A, Bohn C, Bouloc P, Gautheret D (March 2010). "RsaOG, a new staphylococcal family of highly transcribed non-coding RNA". RNA Biol. 7 (2): 116–119. doi:10.4161/rna.7.2.10925. PMID 20200491. Retrieved 2010-07-12.
^ abMarchais A, Naville M, Bohn C, Bouloc P, Gautheret D (June 2009). "Single-pass classification of all noncoding sequences in a bacterial genome using phylogenetic profiles". Genome Res. 19 (6): 1084–1092. doi:10.1101/gr.089714.108. PMC 2694484. PMID 19237465.
^Pichon C, Felden B (October 2005). "Small RNA genes expressed from Staphylococcus aureus genomic and pathogenicity islands with specific expression among pathogenic strains". Proc. Natl. Acad. Sci. U.S.A. 102 (40): 14249–14254. doi:10.1073/pnas.0503838102. PMC 1242290. PMID 16183745.
^ abcGeissmann T, Chevalier C, Cros MJ, et al. (November 2009). "A search for small noncoding RNAs in Staphylococcus aureus reveals a conserved sequence motif for regulation". Nucleic Acids Res. 37 (21): 7239–7257. doi:10.1093/nar/gkp668. PMC 2790875. PMID 19786493.
identified, but not named, in 2005. RsaOG has since been identified in other strains of Staphylococcus aureus under the name of RsaI, it has also been discovered...
ribonucleic antiterminator system, as recognised by GclT protein. RsaOG also renamed RsaI is thought to fine-tune the regulation of toxin or invasion mechanisms...
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