Global InformationRoskamp reaction information
| Roskamp reaction | |
|---|---|
| Named after | Eric J. Roskamp |
| Reaction type | Coupling reaction |
In organic chemistry, the Roskamp reaction is a name reaction describing the reaction between α-diazoesters (such as ethyl diazoacetate) and aldehydes to form β-ketoesters, often utilizing various Lewis acids (such as BF3, SnCl2, and GeCl2) as catalysts.[1][2][3] The reaction is notable for its mild reaction conditions and selectivity.
- ^ Holmquist, Christopher R.; Roskamp, Eric J. (1989-07-01). "A selective method for the direct conversion of aldehydes into β-keto esters with ethyl diazoacetate catalyzed by tin(II) chloride". The Journal of Organic Chemistry. 54 (14): 3258–3260. doi:10.1021/jo00275a006. ISSN 0022-3263.
- ^ Padwa, Albert; Hornbuckle, Susan F.; Zhang, Zhijia; Zhi, Lin (1990). "Synthesis of 1,3-diketones using α-diazo ketones and aldehydes in the presence of tin(II) chloride". The Journal of Organic Chemistry. 55 (18): 5297–5299. doi:10.1021/jo00305a029.
- ^ Guttenberger, Nikolaus; Breinbauer, Rolf (2017). "C-H and C-C bond insertion reactions of diazo compounds into aldehydes". Tetrahedron. 73 (49): 6815–6829. doi:10.1016/j.tet.2017.10.051.