Global InformationRhodopsin kinase information
| G protein-coupled receptor kinase 1 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GRK1 | ||||||
| Alt. symbols | RHOK | ||||||
| NCBI gene | 6011 | ||||||
| HGNC | 10013 | ||||||
| OMIM | 180381 | ||||||
| RefSeq | NM_002929 | ||||||
| UniProt | Q15835 | ||||||
| Other data | |||||||
| EC number | 2.7.11.14 | ||||||
| Locus | Chr. 13 q34 | ||||||
| |||||||
Rhodopsin kinase (EC 2.7.11.14, rod opsin kinase, G-protein-coupled receptor kinase 1, GPCR kinase 1, GRK1, opsin kinase, opsin kinase (phosphorylating), rhodopsin kinase (phosphorylating), RK, STK14) is a serine/threonine-specific protein kinase involved in phototransduction.[1][2][3][4][5][6][7][8] This enzyme catalyses the following chemical reaction:
- ATP + rhodopsin ADP + phospho-rhodopsin
Mutations in rhodopsin kinase are associated with a form of night blindness called Oguchi disease.[9]
- ^ Lorenz W, Inglese J, Palczewski K, Onorato JJ, Caron MG, Lefkowitz RJ (October 1991). "The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase". Proceedings of the National Academy of Sciences of the United States of America. 88 (19): 8715–9. Bibcode:1991PNAS...88.8715L. doi:10.1073/pnas.88.19.8715. PMC 52580. PMID 1656454.
- ^ Benovic JL, Mayor F, Somers RL, Caron MG, Lefkowitz RJ (1986). "Light-dependent phosphorylation of rhodopsin by beta-adrenergic receptor kinase". Nature. 321 (6073): 869–72. Bibcode:1986Natur.321..869B. doi:10.1038/321869a0. PMID 3014340. S2CID 4346322.
- ^ Shichi H, Somers RL (October 1978). "Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase". The Journal of Biological Chemistry. 253 (19): 7040–6. doi:10.1016/S0021-9258(17)38026-2. PMID 690139.
- ^ Palczewski K, McDowell JH, Hargrave PA (October 1988). "Purification and characterization of rhodopsin kinase". The Journal of Biological Chemistry. 263 (28): 14067–73. doi:10.1016/S0021-9258(18)68185-2. PMID 2844754.
- ^ Weller M, Virmaux N, Mandel P (January 1975). "Light-stimulated phosphorylation of rhodopsin in the retina: the presence of a protein kinase that is specific for photobleached rhodopsin". Proceedings of the National Academy of Sciences of the United States of America. 72 (1): 381–5. Bibcode:1975PNAS...72..381W. doi:10.1073/pnas.72.1.381. PMC 432309. PMID 164024.
- ^ Cha K, Bruel C, Inglese J, Khorana HG (September 1997). "Rhodopsin kinase: expression in baculovirus-infected insect cells, and characterization of post-translational modifications". Proceedings of the National Academy of Sciences of the United States of America. 94 (20): 10577–82. Bibcode:1997PNAS...9410577C. doi:10.1073/pnas.94.20.10577. PMC 23407. PMID 9380677.
- ^ Khani SC, Abitbol M, Yamamoto S, Maravic-Magovcevic I, Dryja TP (August 1996). "Characterization and chromosomal localization of the gene for human rhodopsin kinase". Genomics. 35 (3): 571–6. doi:10.1006/geno.1996.0399. PMID 8812493.
- ^ Willets JM, Challiss RA, Nahorski SR (December 2003). "Non-visual GRKs: are we seeing the whole picture?". Trends in Pharmacological Sciences. 24 (12): 626–33. doi:10.1016/j.tips.2003.10.003. PMID 14654303.
- ^ Yamamoto S, Sippel KC, Berson EL, Dryja TP (February 1997). "Defects in the rhodopsin kinase gene in the Oguchi form of stationary night blindness". Nature Genetics. 15 (2): 175–8. doi:10.1038/ng0297-175. PMID 9020843. S2CID 9317102.