Global InformationRemitting seronegative symmetrical synovitis with pitting edema information
| Remitting seronegative symmetrical synovitis with pitting edema | |
|---|---|
| Other names | Remitting seronegative symmetrical synovitis with pitting oedema[1] RS3PE |
| Specialty | Rheumatology |
Remitting seronegative symmetrical synovitis with pitting edema (or sometimes RS3PE) is a rare syndrome identified by symmetric polyarthritis, synovitis, acute pitting edema (swelling) of the back of the hands and/or feet, and a negative serum rheumatoid factor.[2] If no underlying disorder can be identified (idiopathic RS3PE), this entity has an excellent prognosis and responds well to treatment.[3]
RS3PE typically involves the joints of the extremities, specifically the metacarpophalangeal and proximal interphalangeal joints, wrists, shoulders, elbows, knees and ankles.[4] It is more common in older adults, with the mean age between 70 and 80 years in most studies.[4][5] It occurs more often in men than in women with a 2:1 ratio.[4][6][7] It is unknown how common this condition is.
- ^ 'Oedema' is the standard form defined in the Concise Oxford English Dictionary (2011), with the precision that the spelling in the United States is 'edema'.
- ^ Olivieri I, Salvarani C, Cantini F (2000). "RS3PE syndrome: an overview". Clin. Exp. Rheumatol. 18 (4 Suppl 20): S53–55. PMID 10948764.
- ^ Queiro R (March 2004). "RS3PE syndrome: a clinical and immunogenetical study". Rheumatol. Int. 24 (2): 103–05. doi:10.1007/s00296-003-0330-3. PMID 12750942. S2CID 22516577.
- ^ a b c Olivé A, del Blanco J, Pons M, Vaquero M, Tena X (February 1997). "The clinical spectrum of remitting seronegative symmetrical synovitis with pitting edema. The Catalán Group for the Study of RS3PE". J. Rheumatol. 24 (2): 333–36. PMID 9034993.
- ^ Cite error: The named reference
pmid10364902was invoked but never defined (see the help page). - ^ Salam A, Henry R, Sheeran T (2008). "Acute onset polyarthritis in older people: Is it RS3PE syndrome?". Cases J. 1 (1): 132. doi:10.1186/1757-1626-1-132. PMC 2543002. PMID 18759976.
- ^ Hartley AJ, Manson J, Jawad AS (2010). "Remitting seronegative symmetrical synovitis with pitting oedema". Grand Rounds. 10: 71–73. doi:10.1102/1470-5206.2010.0015 (inactive 31 January 2024). Archived from the original on 2011-07-11. Retrieved 2010-12-20.
{{cite journal}}: CS1 maint: DOI inactive as of January 2024 (link)