intrinsic component of the cytoplasmic side of the plasma membrane
plasma membrane
Biological process
intracellular signal transduction
regulation of GTPase activity
MAPK cascade
negative regulation of GTPase activity
signal transduction
positive regulation of GTPase activity
negative regulation of Ras protein signal transduction
cellular response to calcium ion
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
10156
54153
Ensembl
ENSG00000105808
ENSMUSG00000004952
UniProt
O43374
Q6PFQ7
RefSeq (mRNA)
NM_001079877 NM_006989
NM_001039103 NM_133914
RefSeq (protein)
NP_001073346 NP_008920
NP_001034192 NP_598675
Location (UCSC)
Chr 7: 102.58 – 102.62 Mb
Chr 5: 136.08 – 136.11 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[5][6]
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[6]
^ abcGRCh38: Ensembl release 89: ENSG00000105808 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000004952 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene. This gene encodes a member of the GAP1 family of GTPase-activating...