Predicted secondary structure and sequence conservation of PrrF
Identifiers
Symbol
PrrF
Rfam
RF00444
Other data
RNA type
Gene; sRNA
Domain(s)
Bacteria
SO
SO:0000655
PDB structures
PDBe
The PrrF RNAs are small non-coding RNAs involved in iron homeostasis and are encoded by all Pseudomonas species. The PrrF RNAs are analogs of the RyhB RNA, which is encoded by enteric bacteria. Expression of the PrrF RNAs is repressed by the ferric uptake regulator (Fur) when cells are grown in iron-replete conditions. Under iron limitation, the PrrF RNAs are expressed and act to negatively regulate several genes encoding iron-containing proteins, including SodB and succinate dehydrogenase.[1] As such, PrrF regulation "spares" iron when this nutrient becomes scarce.
^Wilderman PJ, Sowa NA, FitzGerald DJ, FitzGerald PC, Gottesman S, Ochsner UA, Vasil ML (June 2004). "Identification of tandem duplicate regulatory small RNAs in Pseudomonas aeruginosa involved in iron homeostasis". Proceedings of the National Academy of Sciences of the United States of America. 101 (26): 9792–9797. Bibcode:2004PNAS..101.9792W. doi:10.1073/pnas.0403423101. PMC 470753. PMID 15210934.
The PrrFRNAs are small non-coding RNAs involved in iron homeostasis and are encoded by all Pseudomonas species. The PrrFRNAs are analogs of the RyhB...
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