Scheme of renal tubule and its vascular supply. (1st convoluted tubule labeled at center top.)
Details
Precursor
Metanephric blastema
Identifiers
Latin
tubulus proximalis, pars tubuli proximalis
MeSH
D007687
Anatomical terminology
[edit on Wikidata]
The proximal tubule is the segment of the nephron in kidneys which begins from the renal pole of the Bowman's capsule to the beginning of loop of Henle. At this location, the glomerular parietal epithelial cells (PECs) lining bowman’s capsule abruptly transition to proximal tubule epithelial cells (PTECs). The proximal tubule can be further classified into the proximal convoluted tubule (PCT) and the proximal straight tubule (PST).
to proximaltubule epithelial cells (PTECs). The proximaltubule can be further classified into the proximal convoluted tubule (PCT) and the proximal straight...
The tubule has five anatomically and functionally different parts: the proximaltubule, which has a convoluted section the proximal convoluted tubule followed...
be differentiated from cells of the proximal convoluted tubule: 1 Glomerulus, 2 proximaltubule, 3 distal tubule Transverse section of pyramidal substance...
microscopically small tubuleProximal convoluted tubule: the portion of the nephron immediately after the glomerulus Renal tubule: the minute canals made...
concentration in the end of the proximaltubule being the same as in the beginning. In other words, the reabsorption in the proximaltubule is isosmotic. Sodium...
inhibitors inhibit the enzyme carbonic anhydrase which is found in the proximal convoluted tubule. This results in several effects including bicarbonate accumulation...
/fɑːnˈkoʊni/, /fæn-/) is a syndrome of inadequate reabsorption in the proximal renal tubules of the kidney. The syndrome can be caused by various underlying...
mellitus. Firstly, the glucose in the proximaltubule is co-transported with sodium ions into the proximal convoluted tubule walls via the SGLT2 cotransporter...
alkaline) from the filtrate in the early portion of the nephron (the proximaltubule). Although a metabolic acidosis also occurs in those with chronic kidney...
Water is 55% reabsorbed in the proximaltubule. Glucose at normal plasma levels is completely reabsorbed in the proximaltubule. The mechanism for this is...
The filtrate passes into the renal tubules of the kidney. In the first part of the renal tubule, the proximaltubule, glucose is reabsorbed from the filtrate...
the distal end with the proximal end joining the alimentary canal at the junction between the midgut and hindgut. Most tubules are normally highly convoluted...
portion is removed and stored in ferritin or hemosiderin. The tubule cells of the proximaltubule become damaged, slough off with the hemosiderin and are excreted...
physiology, resulting in a 100% reabsorption in the proximaltubule. In the renal proximaltubule, there are several kinds of carboxylate transporters...
substantial deposition of hemosiderin in proximaltubule (excessive accumulation of hemosiderin in proximaltubule), Fanconi syndrome (damaged renal re-absorption...
increased Na+–H+ exchange in the proximaltubule and increased HCO3− (bicarbonate) reabsorption in the proximaltubule due to increased luminal H+. Increased...
into the renal tubules. Flow continues through the renal tubules, including the proximaltubule, the loop of Henle, through the distal tubule and finally...
study for paracellular transport across the tight junction in kidney proximaltubule, a dual pathway model was proposed, consisting of large slit breaks...
secretion occurs at Proximal Convoluted Tubule (PCT) and Distal Convoluted Tubule (D.C.T); for example, at proximal convoluted tubule, potassium is secreted...
necrosis of the epithelial lining in renal tubules, with focal rupture or loss of basement membrane. Proximaltubule cells can shed with variable viability...
in fact, other transporters such as the Na+-H+ antiporter in the proximaltubule or the Na+/K+/2Cl− symporter in the thick ascending loop of Henle were...
cells) are a marsupial cell line used in medical research to model proximaltubule epithelial cells of the kidney. The cell line was derived from the...
urea. Cells of the proximaltubule have numerous microvilli and mitochondria which provide surface area and energy to the proximaltubule cells. The blood...
epithelial cells in the proximaltubule of the kidney. It is highly expressed in the first segment (S1) of the proximaltubule, with decreasing expression...
glomerulus has also been documented. Following an acute injury, the proximaltubule is damaged more, and the injured epithelial cells slough off the basement...
sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximaltubule of the kidney. Sulfinpyrazone must not be used in persons with renal...