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Proximal tubule information


Proximal tubule
Scheme of renal tubule and its vascular supply. (1st convoluted tubule labeled at center top.)
Details
PrecursorMetanephric blastema
Identifiers
Latintubulus proximalis, pars tubuli proximalis
MeSHD007687
Anatomical terminology
[edit on Wikidata]

The proximal tubule is the segment of the nephron in kidneys which begins from the renal pole of the Bowman's capsule to the beginning of loop of Henle. At this location, the glomerular parietal epithelial cells (PECs) lining bowman’s capsule abruptly transition to proximal tubule epithelial cells (PTECs). The proximal tubule can be further classified into the proximal convoluted tubule (PCT) and the proximal straight tubule (PST).

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Proximal tubule

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to proximal tubule epithelial cells (PTECs). The proximal tubule can be further classified into the proximal convoluted tubule (PCT) and the proximal straight...

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Nephron

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The tubule has five anatomically and functionally different parts: the proximal tubule, which has a convoluted section the proximal convoluted tubule followed...

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Distal convoluted tubule

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be differentiated from cells of the proximal convoluted tubule: 1 Glomerulus, 2 proximal tubule, 3 distal tubule Transverse section of pyramidal substance...

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Tubule

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microscopically small tubule Proximal convoluted tubule: the portion of the nephron immediately after the glomerulus Renal tubule: the minute canals made...

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Renal sodium reabsorption

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concentration in the end of the proximal tubule being the same as in the beginning. In other words, the reabsorption in the proximal tubule is isosmotic. Sodium...

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Diuretic

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inhibitors inhibit the enzyme carbonic anhydrase which is found in the proximal convoluted tubule. This results in several effects including bicarbonate accumulation...

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Fanconi syndrome

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/fɑːnˈkoʊni/, /fæn-/) is a syndrome of inadequate reabsorption in the proximal renal tubules of the kidney. The syndrome can be caused by various underlying...

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Renal glucose reabsorption

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mellitus. Firstly, the glucose in the proximal tubule is co-transported with sodium ions into the proximal convoluted tubule walls via the SGLT2 cotransporter...

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Renal tubular acidosis

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alkaline) from the filtrate in the early portion of the nephron (the proximal tubule). Although a metabolic acidosis also occurs in those with chronic kidney...

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Kidney

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Water is 55% reabsorbed in the proximal tubule. Glucose at normal plasma levels is completely reabsorbed in the proximal tubule. The mechanism for this is...

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Glycosuria

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The filtrate passes into the renal tubules of the kidney. In the first part of the renal tubule, the proximal tubule, glucose is reabsorbed from the filtrate...

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Malpighian tubule system

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the distal end with the proximal end joining the alimentary canal at the junction between the midgut and hindgut. Most tubules are normally highly convoluted...

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Hemosiderinuria

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portion is removed and stored in ferritin or hemosiderin. The tubule cells of the proximal tubule become damaged, slough off with the hemosiderin and are excreted...

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Carboxylate transporter

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physiology, resulting in a 100% reabsorption in the proximal tubule. In the renal proximal tubule, there are several kinds of carboxylate transporters...

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Intravascular hemolysis

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substantial deposition of hemosiderin in proximal tubule (excessive accumulation of hemosiderin in proximal tubule), Fanconi syndrome (damaged renal re-absorption...

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Contraction alkalosis

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increased Na+–H+ exchange in the proximal tubule and increased HCO3− (bicarbonate) reabsorption in the proximal tubule due to increased luminal H+. Increased...

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Renal medulla

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into the renal tubules. Flow continues through the renal tubules, including the proximal tubule, the loop of Henle, through the distal tubule and finally...

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Tight junction

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study for paracellular transport across the tight junction in kidney proximal tubule, a dual pathway model was proposed, consisting of large slit breaks...

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Renal physiology

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secretion occurs at Proximal Convoluted Tubule (PCT) and Distal Convoluted Tubule (D.C.T); for example, at proximal convoluted tubule, potassium is secreted...

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Acute tubular necrosis

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necrosis of the epithelial lining in renal tubules, with focal rupture or loss of basement membrane. Proximal tubule cells can shed with variable viability...

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Aldosterone escape

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in fact, other transporters such as the Na+-H+ antiporter in the proximal tubule or the Na+/K+/2Cl− symporter in the thick ascending loop of Henle were...

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OK cells

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cells) are a marsupial cell line used in medical research to model proximal tubule epithelial cells of the kidney. The cell line was derived from the...

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Osmoregulation in rock doves

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urea. Cells of the proximal tubule have numerous microvilli and mitochondria which provide surface area and energy to the proximal tubule cells. The blood...

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LRP2

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epithelial cells in the proximal tubule of the kidney. It is highly expressed in the first segment (S1) of the proximal tubule, with decreasing expression...

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Regeneration in humans

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glomerulus has also been documented. Following an acute injury, the proximal tubule is damaged more, and the injured epithelial cells slough off the basement...

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Sulfinpyrazone

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sulfinpyrazone works by competitively inhibiting uric acid reabsorption in the proximal tubule of the kidney. Sulfinpyrazone must not be used in persons with renal...

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