positive regulation of adenosine receptor signaling pathway
purine nucleobase metabolic process
thiamine metabolic process
dephosphorylation
neutrophil degranulation
protein homotetramerization
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
55
56318
Ensembl
ENSG00000014257
ENSMUSG00000032561
UniProt
P15309
Q8CE08
RefSeq (mRNA)
NM_001099 NM_001134194 NM_001292037
NM_019807 NM_207668
RefSeq (protein)
NP_001090 NP_001127666 NP_001278966
NP_062781 NP_997551
Location (UCSC)
Chr 3: 132.32 – 132.37 Mb
Chr 9: 104.17 – 104.21 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Prostatic acid phosphatase (PAP), also prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. It may be found in increased amounts in men who have prostate cancer or other diseases.
The highest levels of acid phosphatase are found in metastasized prostate cancer. Diseases of the bone, such as Paget's disease or hyperparathyroidism, diseases of blood cells, such as sickle-cell disease or multiple myeloma or lysosomal storage diseases, such as Gaucher's disease, will show moderately increased levels.
Certain medications can cause temporary increases or decreases in acid phosphatase levels. Manipulation of the prostate gland through massage, biopsy or rectal exam before a test may increase the level.
Its physiological function may be associated with the liquefaction process of semen.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000014257 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000032561 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Page 1135-1136 in: Walter F. Boron (2003). Medical Physiology: A Cellular And Molecular Approaoch. Elsevier/Saunders. p. 1300. ISBN 978-1-4160-2328-9.
and 24 Related for: Prostatic acid phosphatase information
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epitopes. In the case of Provenge, this disease related protein is prostaticacidphosphatase and the signalling component is GM-CSF. Dendreon believes its...
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The enzyme alkaline phosphatase (ALP, alkaline phenyl phosphatase) is a phosphatase with the physiological role of dephosphorylating compounds. The enzyme...
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Lysophosphatidic acidphosphatase type 6 is an acidphosphatase enzyme that is encoded in humans by the ACP6 gene. It acts as a phosphomonoesterase at...
issues other than prostate cancer such as benign prostatic hyperplasia (non-cancerous enlargement of the prostate). Advanced prostate tumors can metastasize...
vaccine-like strategy for prostate cancer in which dendritic cells from the patient are loaded with prostaticacidphosphatase peptides to induce a specific...
with the fusion protein PA2024 made from GM-CSF and prostate-specific prostaticacidphosphatase (PAP) and reinfused. This process is repeated three times...
the superfamily that also contains the phosphatase portion of phosphofructokinase 2 and prostaticacidphosphatase. The catalyzed mutase reaction involves...
of advanced prostatic cancer. Efficacy and cardiovascular complications: a 2-year follow-up report of a national, prospective prostatic cancer study...
CD30 hPG80 Prostate cancer Prostate-specific antigen Prostaticacidphosphatase Glutamate carboxypeptidase II erbB-3 receptor Early prostate cancer antigen-2...
Earlier studies with bicalutamide instead assessed changes in prostaticacidphosphatase (PAP) levels; proportions of patients with decreases of PAP of...
and carcinoid-like tumors, as well as prostatic adenocarcinoma exhibiting focal neuroendocrine phenotype. Prostatic neuroendocrine cells, also known as...
Lipid phosphate phosphohydrolase 1 also known as phosphatidic acidphosphatase 2a is an enzyme that in humans is encoded by the PPAP2A gene. Lipid phosphate...
Réhault S, Juliano L, et al. (2002). "Amidolytic activity of prostaticacidphosphatase on human semenogelins and semenogelin-derived synthetic substrates"...
associated with Gaucher disease Public-safety answering point Prostatic-specific acidphosphatase Personal sound amplification products Presentation Service...
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