Proser2 information

PROSER2
Identifiers
Aliases	PROSER2, C10orf47, proline and serine rich 2
External IDs	MGI: 2442238; HomoloGene: 51648; GeneCards: PROSER2; OMA:PROSER2 - orthologs
Gene location (Human)
Chr.	Chromosome 10 (human)
End	11,872,277 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	6,135,022 bp
RNA expression pattern
	Top expressed in
	pancreatic ductal cell; ; amniotic fluid; ; right lobe of liver; ; secondary oocyte; ; endothelial cell; ; tibial nerve; ; tibia; ; right lung; ; upper lobe of left lung; ; palpebral conjunctiva;
	Top expressed in
	molar; ; lacrimal gland; ; lip; ; esophagus; ; conjunctival fornix; ; salivary gland; ; urinary bladder; ; parotid gland; ; hair follicle; ; cumulus cell;
	More reference expression data
	n/a
Orthologs
	254427
	227545
	ENSG00000148426
	ENSMUSG00000045319
	Q86WR7
	Q8C5R2
	NM_153256
	NM_001159657; NM_144883
	NP_694988
	NP_001153129; NP_659132
	Wikidata
View/Edit Human	View/Edit Mouse

PROSER2, also known as proline and serine rich 2, is a protein that in humans is encoded by the PROSER2 gene. PROSER2, or c10orf47 (Chromosome 10 open reading frame 47), is found in band 14 of the short arm of chromosome 10 (10p14) and contains a highly conserved SARG domain.^[5]^[6] It is a fast evolving gene with two paralogs, c1orf116 and specifically androgen-regulated gene protein isoform 1.^[5]^[7]^[8] The PROSER2 protein has a currently uncharacterized function however, in humans, it may play a role in cell cycle regulation, reproductive functioning, and is a potential biomarker of cancer.^[9]^[10]^[11]^[12]^[13]^[14]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000148426 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000045319 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b NCBI (National Center for Biotechnology Information) Protein
^ Cite error: The named reference :15 was invoked but never defined (see the help page).
^ NCBI BLAST (National Center for Biotechnology Information Basic Local Alignment Search Tool ) [http://blast.ncbi.nlm.nih.gov/Blast.cgi]
^ Time Tree [http://www.timetree.org/]
^ Pawlowski,T.,Yeatts, K., and Akhavan, R. (2012). Circulating biomarkers for cancer.
^ Birrer, M.J., Bonome, T.A., Sood, A., and LU, C. (2013). Pro-angiogenic genes in ovarian tumor endothelial cell isolates.
^ Nguyen,L.S., Kim, H.-G., Rosenfeld, J.A., Shen, Y., Gusella, J.F., Lacassie, Y., Layman, L.C., Shaffer, L.G., and Gécz, J. (2013). Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders. Hum. Mol. Genet. 22, 1816–1825.
^ Schettini, J., Hornung, T., Holterman, D., and Spetzler, D. (2014). Biomarker compositions and methods.
^ Seto, M., Tagawa, H., Yoshida, Y., and Kira, S. (2008). Methods for Diagnosis and Prognosis of Malignant Lymphoma.
^ Zarbl, H., and Graham, J. (2014). Novel Method of Cancer Diagnosis and Prognosis and Prediction of Response to Therapy.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000148426 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000045319 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] NCBI (National Center for Biotechnology Information) Protein

[:15-6] Cite error: The named reference :15 was invoked but never defined (see the help page).

[:7-7] NCBI BLAST (National Center for Biotechnology Information Basic Local Alignment Search Tool ) [http://blast.ncbi.nlm.nih.gov/Blast.cgi]

[:6-8] Time Tree [http://www.timetree.org/]

[:8-9] Pawlowski,T.,Yeatts, K., and Akhavan, R. (2012). Circulating biomarkers for cancer.

[:9-10] Birrer, M.J., Bonome, T.A., Sood, A., and LU, C. (2013). Pro-angiogenic genes in ovarian tumor endothelial cell isolates.

[:10-11] Nguyen,L.S., Kim, H.-G., Rosenfeld, J.A., Shen, Y., Gusella, J.F., Lacassie, Y., Layman, L.C., Shaffer, L.G., and Gécz, J. (2013). Contribution of copy number variants involving nonsense-mediated mRNA decay pathway genes to neuro-developmental disorders. Hum. Mol. Genet. 22, 1816–1825.

[:11-12] Schettini, J., Hornung, T., Holterman, D., and Spetzler, D. (2014). Biomarker compositions and methods.

[:12-13] Seto, M., Tagawa, H., Yoshida, Y., and Kira, S. (2008). Methods for Diagnosis and Prognosis of Malignant Lymphoma.

[:13-14] Zarbl, H., and Graham, J. (2014). Novel Method of Cancer Diagnosis and Prognosis and Prediction of Response to Therapy.