Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Propargylamine is an organic compound with the formula HC≡CCH2NH2. It is a colorless, odorless liquid that is used as a precursor to other compounds.[1] Propargyl amines are produced by reactions of amines with propargyl halides.
The behavior of propargyl amine is illustrated by its acylation benzoyl chloride to the amide. A Sonogashira coupling of the terminal alkyne end with another equivalent of benzoylchloride gives the dicarbonyl, a precursor to an oxazole.[2]
^Lauder, Kate; Toscani, Anita; Scalacci, Nicolò; Castagnolo, Daniele (2017). "Synthesis and Reactivity of Propargylamines in Organic Chemistry". Chemical Reviews. 117 (24): 14091–14200. doi:10.1021/acs.chemrev.7b00343. PMID 29166000.
^A new consecutive three-component oxazole synthesis by an amidation–coupling–cycloisomerization (ACCI) sequence Eugen Merkul and Thomas J. J. Müller Chem. Commun., 2006, 4817 - 4819, doi:10.1039/b610839c
Propargylamine is an organic compound with the formula HC≡CCH2NH2. It is a colorless, odorless liquid that is used as a precursor to other compounds. Propargyl...
rasagiline is used with other MAO inhibitors. Rasagiline is molecularly a propargylamine derivative. The form brought to market by Teva and its partners is the...
2005). "Clinical pharmacology of rasagiline: a novel, second-generation propargylamine for the treatment of Parkinson disease". Journal of Clinical Pharmacology...
refer to: 1-Azabicyclo[1.1.0]butane 1-Azetine (dihydroazete) 2-Azetine Propargylamine (2-propynylamine) Propionitrile (propanenitrile) This set index page...
out. The first is the amidation of the oligopeptide's C-terminus by propargylamine. This would done with all other reaction groups protected and with the...
involving an aldehyde, an alkyne and an amine which react to give a propargylamine. The reaction proceeds via direct dehydrative condensation and requires...
of aldehydes, amine with phenylacetylene to give the corresponding propargylamines. The catalyst can be reused three times without remarkable reduce in...
sensitive to semicarbazide and other hydrazines, hydroxylamine and propargylamine. VAP-1 is found in the smooth muscle of blood vessels and various other...
Edukondalu (2016). "Diastereoselective Synthesis of Tetrasubstituted Propargylamines via Hydroamination and Metalation of 1-Alkynes and Their Enantioselective...
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