Global InformationPredimed information
 | Parts of this article (those related to the retracted study need to be removed, with accompanying text, and replaced by the 2018 study) need to be updated. (June 2018) |
PREDIMED (Prevención con Dieta Mediterránea (Prevention with Mediterranean Diet[1])) was a large Spanish primary prevention trial which included 7,447 Spanish participants (55–80 years, 58% women) who were at high risk for cardiovascular disease, but otherwise healthy (initially free of cardiovascular disease). They were randomly assigned to receive interventions with intensive education to one of three diets:
- Mediterranean diet supplemented with extra-virgin olive oil.
- Mediterranean diet supplemented with nuts.
- Control diet encouraging low-fat food items.
The trial was planned for six years, but it was terminated early after a median follow-up of 4.8 years, and demonstrated that both Mediterranean diet groups reached a statistically significant reduction in the rate of the composite cardiovascular primary end-point of myocardial infarction, stroke, or cardiovascular death.[2] This corresponded to an absolute reduction in 3 less cardiovascular events per 1000 patient-years, or a 30% relative risk reduction. Other important observed benefits included a strong reduction in peripheral artery disease,[3] breast cancer,[4] and atrial fibrillation (only associated with the consumption of extra-virgin olive oil).[5]
- ^ Martínez-González, Miguel A.; Salas-Salvadó, Jordi; Estruch, Ramón; Corella, Dolores; Fitó, Montse; Ros, Emilio; PREDIMED INVESTIGATORS (2016-08-01). "Benefits of the Mediterranean Diet: Insights From the PREDIMED Study". Progress in Cardiovascular Diseases. 58 (1): 50–60. doi:10.1016/j.pcad.2015.04.003. hdl:10230/25644. ISSN 1873-1740. PMID 25940230.
- ^ Estruch, Ramón; Ros, Emilio; Salas-Salvadó, Jordi; Covas, Maria-Isabel; Corella, Dolores; Arós, Fernando; Gómez-Gracia, Enrique; Ruiz-Gutiérrez, Valentina; Fiol, Miquel (2013-04-04). "Primary prevention of cardiovascular disease with a Mediterranean diet". The New England Journal of Medicine. 368 (14): 1279–1290. doi:10.1056/NEJMoa1200303. hdl:10171/28216. ISSN 1533-4406. PMID 23432189. (Retracted, see PMID 29897867)
- ^ Ruiz-Canela, Miguel; Estruch, Ramón; Corella, Dolores; Salas-Salvadó, Jordi; Martínez-González, Miguel A. (2017-01-22). "Association of Mediterranean diet with peripheral artery disease: the PREDIMED randomized trial". JAMA. 311 (4): 415–417. doi:10.1001/jama.2013.280618. hdl:2445/119828. ISSN 1538-3598. PMID 24449321.
- ^ Toledo, Estefanía; Salas-Salvadó, Jordi; Donat-Vargas, Carolina; Buil-Cosiales, Pilar; Estruch, Ramón; Ros, Emilio; Corella, Dolores; Fitó, Montserrat; Hu, Frank B. (2015-11-01). "Mediterranean Diet and Invasive Breast Cancer Risk Among Women at High Cardiovascular Risk in the PREDIMED Trial: A Randomized Clinical Trial". JAMA Internal Medicine. 175 (11): 1752–1760. doi:10.1001/jamainternmed.2015.4838. hdl:10230/33360. ISSN 2168-6114. PMID 26365989.
- ^ Martínez-González, Miguel Á; Toledo, Estefanía; Arós, Fernando; Fiol, Miquel; Corella, Dolores; Salas-Salvadó, Jordi; Ros, Emilio; Covas, Maria I.; Fernández-Crehuet, Joaquín (2014-07-01). "Extravirgin olive oil consumption reduces risk of atrial fibrillation: the PREDIMED (Prevención con Dieta Mediterránea) trial". Circulation. 130 (1): 18–26. doi:10.1161/CIRCULATIONAHA.113.006921. hdl:10553/44645. ISSN 1524-4539. PMID 24787471.