Visualization of living animals for research purposes
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Preclinical imaging is the visualization of living animals for research purposes,[1] such as drug development. Imaging modalities have long been crucial to the researcher in observing changes, either at the organ, tissue, cell, or molecular level, in animals responding to physiological or environmental changes. Imaging modalities that are non-invasive and in vivo have become especially important to study animal models longitudinally. Broadly speaking, these imaging systems can be categorized into primarily morphological/anatomical and primarily molecular imaging techniques.[2] Techniques such as high-frequency micro-ultrasound, magnetic resonance imaging (MRI) and computed tomography (CT) are usually used for anatomical imaging, while optical imaging (fluorescence and bioluminescence), positron emission tomography (PET), and single photon emission computed tomography (SPECT) are usually used for molecular visualizations.[2]
These days, many manufacturers provide multi-modal systems combining the advantages of anatomical modalities such as CT and MR with the functional imaging of PET and SPECT. As in the clinical market, common combinations are SPECT/CT, PET/CT and PET/MR.[citation needed]
^Kiessling F, Pichler BJ (2011). Small Animal Imaging: Basics and Practical Guide (1st ed.). Springer. ISBN 978-3-642-12944-5.
^ abWillmann JK, van Bruggen N, Dinkelborg LM, Gambhir SS (July 2008). "Molecular imaging in drug development". Nature Reviews. Drug Discovery. 7 (7): 591–607. doi:10.1038/nrd2290. PMID 18591980. S2CID 37571813.
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