Predicted secondary structure and sequence conservation of PreQ1
Identifiers
Symbol
PreQ1
Rfam
RF00522
Other data
RNA type
Cis-reg; riboswitch
Domain(s)
Bacteria
SO
SO:0000035
PDB structures
PDBe 2L1V
The PreQ1-I riboswitch is a cis-acting element identified in bacteria which regulates expression of genes involved in biosynthesis of the nucleoside queuosine (Q) from GTP.[1] PreQ1 (pre-queuosine1) is an intermediate in the queuosine pathway, and preQ1 riboswitch, as a type of riboswitch, is an RNA element that binds preQ1. The preQ1 riboswitch is distinguished by its unusually small aptamer, compared to other riboswitches. Its atomic-resolution three-dimensional structure has been determined, with the PDB ID 2L1V.[2][3]
^Roth A, Winkler WC, Regulski EE, Lee BW, Lim J, Jona I, Barrick JE, Ritwik A, Kim JN, Welz R, Iwata-Reuyl D, Breaker RR (2007). "A riboswitch selective for the queuosine precursor preQ1 contains an unusually small aptamer domain". Nat Struct Mol Biol. 14 (4): 308–317. doi:10.1038/nsmb1224. PMID 17384645. S2CID 32367656.
^Klein DJ, Edwards TE, Ferré-D'Amaré AR (March 2009). "Cocrystal structure of a class I preQ1 riboswitch reveals a pseudoknot recognizing an essential hypermodified nucleobase". Nat. Struct. Mol. Biol. 16 (3): 343–344. doi:10.1038/nsmb.1563. PMC 2657927. PMID 19234468.
^Kang M, Peterson R, Feigon J (March 2009). "Structural Insights into riboswitch control of the biosynthesis of queuosine, a modified nucleotide found in the anticodon of tRNA". Mol. Cell. 33 (6): 784–790. doi:10.1016/j.molcel.2009.02.019. PMID 19285444.
PreQ1 (pre-queuosine1) is an intermediate in the queuosine pathway, and preQ1riboswitch, as a type of riboswitch, is an RNA element that binds preQ1...
are PreQ1-III riboswitches. Purine riboswitches binds purines to regulate purine metabolism and transport. Different forms of the purine riboswitch bind...
conserved and the queA gene itself is never known to be regulated by a preQ1riboswitch, it is not likely that queA RNAs correspond to riboswitches. Weinberg...
classes of riboswitch are known to regulate genes that are involved in the synthesis or transport of pre-queuosine1, a precursor to queuosine: PreQ1-I riboswitches...