Global InformationPom1 information
| Pom1 | |
|---|---|
| Identifiers | |
| Organism | |
| Symbol | SPAC2F7.03c |
| Entrez | 2541889 |
Pom1 is a polarity protein kinase in fission yeast, Schizosaccharomyces pombe (S. pombe), that localizes to cell ends and regulates cell division. As the cell lengthens, the level of Pom1 in the middle declines, which triggers mitosis.[1]
The gene pom1 codes for a protein 1087 amino acids long with the protein kinase domain likely located at the carboxyl terminus.[1] Pom1 regulates a signaling pathway that includes Cdk1 and ultimately regulates mitotic entry.[2] Cells with mutant pom1 form a septa and growth zone, but show a host of abnormalities including misplaced or misoriented septa, bi-polar growth replaced with random growth at one end, or the mislocalization of the growth axis leading to abnormal branching.[1][3]
Pom1 plays an important role in differentiating the old and new end of an S. pombe cell. Normal cell growth begins immediately in the old end of the cell and is delayed in the new end.[3] pom1 mutants show immediate growth at both ends. Since Pom1 has been shown to be highly concentrated at the new end and nearly absent from the old end, it, along with other factors are part of an inhibitory signal that prevents immediate growth from the new end.[1] Overexpression of Pom1 can also lead to the formation of new growth ends.[3]
Pom1 is a relatively unique protein kinase as its closest homolog in S. pombe is only 55% identical. Homologs in other organisms include Dyrk in rats, Dyrk2 and Dyrk3 in humans, Yak1p in S. cerevisiae,[4] and Minibrain in Drosophila and humans.[1][5]
- ^ a b c d e Bahler, J., and Pringle, J.R. “Pom1p, a fission yeast protein kinase that provides positional information for both polarized growth and cytokinesis.” Genes and Development 12, 1356-1370 (1998).
- ^ Moseley, J.B., Mayeux, A., Paoletti, A. and Nurse, P. “A spatial gradient coordinates cell size and mitotic entry in fission yeast.” Nature 459, 857-861 (2009).
- ^ a b c Bahler, J., and Nurse, P. “Fission yeast Pom1p kinase activity is cell cycle regulated and essential for cellular symmetry during growth and division.” The EMBO Journal 20, 1064-1073 (2001).
- ^ Souza, G.M., Lu, S., and Kuspa, A. “YakA, a protein kinase required for the transition from growth to development in Dictyostelium. Development 125, 2291-2302 (1998).
- ^ Tejedor, F., Zhu, X.R., Kaltenbach, E., Ackermann, A., Baumann, A., Canal, I., Heisenberg, M., Fischbach, K.F., and Pongs, O. “Minibrain: A new protein kinase family involved in postembryonic neurogenesis in Drosophila. Neuron 14, 287-301 (1995).