Pharmacometrics is a field of study of the methodology and application of models for disease and pharmacological measurement. It uses mathematical models of biology, pharmacology, disease, and physiology to describe and quantify interactions between xenobiotics and patients (human and non-human), including beneficial effects and adverse effects.[1] It is normally applied to quantify drug, disease and trial information to aid efficient drug development, regulatory decisions and rational drug treatment in patients.
Pharmacometrics uses models based on pharmacology, physiology, and disease for quantitative analysis of interactions between drugs and patients. This involves Systems pharmacology, pharmacokinetics, pharmacodynamics and disease progression with a focus on populations and variability.
Mould and Upton provide an overview of basic concepts in population modeling, simulation, and model-based drug development.[2]
A major focus of pharmacometrics is to understand variability in drug response. Variability may be predictable (e.g. due to differences in body weight or kidney function) or apparently unpredictable (a reflection of the current lack of knowledge).
^Barrett JS, Fossler MJ, Cadieu KD, Gastonguay MR (May 2008). "Pharmacometrics: a multidisciplinary field to facilitate critical thinking in drug development and translational research settings". Journal of Clinical Pharmacology. 48 (5): 632–49. doi:10.1177/0091270008315318. PMID 18440922. S2CID 32648945.
^Mould DR, Upton RN (September 2012). "Basic concepts in population modeling, simulation, and model-based drug development". CPT: Pharmacometrics & Systems Pharmacology. 1 (9): e6. doi:10.1038/psp.2012.4. PMC 3606044. PMID 23835886.
The term "pharmacometrics" first appeared in literature in the preface of the 1964 book "Evaluation of Drug Activities: Pharmacometrics": The sub-title...
especially powerful in the context of population pharmacokinetics, pharmacometrics, and PK/PD models. NONMEM models are written in NMTRAN, a dedicated...
processes and drug pharmacology. QSP can be viewed as a sub-discipline of pharmacometrics that focuses on modeling the mechanisms of drug pharmacokinetics (PK)...
also the preprocessor which expands that notation to MusiXTeX code. Pharmacometrics, a discipline that develops mathematical models of biology, pharmacology...
lives in the United Kingdom and from 1976 has been a professor of pharmacometrics at the University of Manchester. In the interest of promoting the effective...
behaviour. D R Laurence, A. L. Bacharach Evaluation of Drug Activities: Pharmacometrics 1483263460 2013 p.177 "PSYCHOTOXICITY (a) Test Methods Drug-induced...
Interaction Between Autophagy and Apoptosis in Mammalian Cells". CPT: Pharmacometrics & Systems Pharmacology. 4 (4): 263–72. doi:10.1002/psp4.29. PMC 4429580...
Dose Toxicity Study of Methylsulfonylmethane in Mice". Oyo Yakuri Pharmacometrics. 79: 23–30. Kim LS, Axelrod LJ, Howard P, Buratovich N, Waters RF (March...
insufficient in-house expertise and resources in drug synthesis, formulation, pharmacometrics, and bio-analysis. The Keck Graduate Institute Center for Rare Disease...
Bioequivalence Evaluation: Report of an FDA Public Workshop". CPT: Pharmacometrics & Systems Pharmacology. 6 (8): 492–495. doi:10.1002/psp4.12204. ISSN 2163-8306...
systems pharmacology, which is the integration of systems biology and pharmacometrics. Systems biology characterizes (part of) an organism by a mathematical...
With Advanced Solid Tumors and Children With Low-Grade Gliomas". CPT: Pharmacometrics & Systems Pharmacology. 6 (5): 305–314. doi:10.1002/psp4.12175. PMC 5445231...
(2014-05-28). "Visualization and Communication of Pharmacometric Models With Berkeley Madonna". CPT: Pharmacometrics & Systems Pharmacology. 3 (5): 113. doi:10...
Emphasis in Pharmacometrics or Emphasis in Pharmacy Compounding, and/or certifications in Applied Health Outcomes Research, Pharmacometrics, and Drug Discovery...
tool to bridge efficacy and safety data in special populations". CPT: Pharmacometrics & Systems Pharmacology. 2 (2): e28. doi:10.1038/psp.2013.6. PMC 3600759...
awarded the First Leadership Award of the International Society of Pharmacometrics (ISOP). In 2015 he received the Merit Medal of the Westphalian Chamber...
Frontiers Media Nestlé Institute of Health Sciences Merck Institute for Pharmacometrics Musée Bolo Archizoom UNIL-EPFL common structures: Language Centre Sport...
of disease, defined pharmacometric parameters in MRONJ patients and developed a statistical Bayesian-based population pharmacometric paradigm for MRONJ...
Desmond Laurence), of the two volume Evaluation of Drug Activities: Pharmacometrics (1964), and (with Otto Edholm) Exploration Medicine (1965) and The...
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