Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references
Chemical compound
Benzylpenicillin, an example of a penam
Not to be confused with penem.
Penams are the primary skeleton structures that define the penicillin subclass of the broader β-lactam family of antibiotics and related compounds. They are bicyclic ring systems containing a β-lactam moiety fused with a five-member thiazolidine ring. [1] Due to ring strain and limitations on amide resonance, the structure is unstable and highly susceptible to catalytic cleavage at the amide bond.[2] Benzylpenicillin (penicillin G) is the natural product parent that contains the penam structure.
^Novak, Igor; Chua, Pei Juan (2006-09-01). "Computational Study of Pharmacophores: β-Lactams". The Journal of Physical Chemistry A. 110 (35): 10521–10524. Bibcode:2006JPCA..11010521N. doi:10.1021/jp063162b. ISSN 1089-5639. PMID 16942059.
^Patrick, Graham (2017-03-23), "5. Pharmaceuticals and medicinal chemistry", Organic Chemistry: A Very Short Introduction, Oxford University Press, pp. 71–89, doi:10.1093/actrade/9780198759775.003.0005, ISBN 978-0-19-875977-5
Penams are the primary skeleton structures that define the penicillin subclass of the broader β-lactam family of antibiotics and related compounds. They...
condition is known as livedoid dermatitis or Nicolau syndrome. The term "penam" is used to describe the common core skeleton of a member of the penicillins...
2004). "Beta-lactams in the new millennium. Part-II: cephems, oxacephems, penams and sulbactam". Mini Reviews in Medicinal Chemistry. 4 (1): 93–109. doi:10...
totidem tempore quando reuertuntur ad montem; et si plus stant, incidunt ad penam quingentarum librarum. Mužić 2010, p. 13: Cum rectores Jadre scripserint...
terms of structure, the carbapenems are very similar to the penicillins (penams), but the sulfur atom in position 1 of the structure has been replaced with...
(molar mass: 129.18 g/mol, exact mass: 129.0248 u) may refer to: Goitrin Penam This set index page lists chemical structure articles associated with the...
texts. One reads Cham ridet dum nuda pudibunda parentis; Iudei risere Dei penam mor[ientis], or "Cham laughed when he saw his parent's shameful nudity;...
children, Tenzing Dechen, Tenzing Choyang, Norbu Wangmo, Tashi Chodon, Tulku Penam and Tenzing Tsering, five grandchildren, his mother, and four brothers and...
totidem tempore quando reuertuntur ad montem; et si plus stant, incidunt ad penam quingentarum librarum. Botica 2005, p. 39. Mužić 2010, p. 230. Mužić 2009...
antibiotic and 5S clavams may have anti-fungal properties. They are similar to penams, but with an oxygen substituted for the sulfur. Thus, they are also known...
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