Paul Charles Zamecnik (November 22, 1912 – October 27, 2009) was an American scientist who played a central role in the early history of molecular biology. He was a professor of medicine at Harvard Medical School and a senior scientist at Massachusetts General Hospital.
Zamecnik pioneered the in vitro synthesis of proteins and helped elucidate the way cells generate proteins. With Mahlon Hoagland he co-discovered transfer RNA (tRNA).[1][2] Through his later work, he is credited as the inventor of antisense therapeutics.
Throughout his career, Zamecnik earned over a dozen US patents for his therapeutic techniques. Up until his death in 2009 he maintained a lab at MGH where he studied the application of synthetic oligonucleotides (antisense hybrids) for chemotherapeutic treatment of drug resistant and XDR tuberculosis in his later years.
^Hoagland MB, Zamecnik PC, Stephenson ML (April 1957). "Intermediate Reactions In Protein Biosynthesis". Biochim Biophys Acta. 24 (1): 215–6. doi:10.1016/0006-3002(57)90175-0. PMID 13426231.
^Hoagland MB, Stephenson ML, Scott JF, Hecht LI, Zamecnik PC (March 1958). "A Soluble Ribonucleic Acid Intermediate in Protein Synthesis" (PDF). J Biol Chem. 231 (1): 241–57. doi:10.1016/S0021-9258(19)77302-5. PMID 13538965.
Paul Charles Zamecnik (November 22, 1912 – October 27, 2009) was an American scientist who played a central role in the early history of molecular biology...
and perhaps other relatives. Jan's grandson was the geneticist PaulZamecnik. Zamecnik studied at the Prague Conservatory of Music under Antonín Dvořák...
Nguyen-Huu Xiangzhong Yang J. Scott Yaruss K. Aslihan Yener Mariano Yogore PaulZamecnik Marlene Zuk Biography portal Lists portal Science portal United States...
amino acid to a small RNA molecule. Hoagland and his collaborator, PaulZamecnik, later discovered that the small RNA molecule was a tRNA, and they identified...
Hutchinson, Elvin A. Kabat, Robert Kates, Salvador Luria, Paul Marks, Folke K. Skoog, PaulZamecnik 1992—Maxine Singer, Howard Martin Temin 1993—Daniel Nathans...
Junying Yuan, 1989, professor of cell biology at Harvard Medical School PaulZamecnik, 1936, professor of oncologic medicine at Harvard Medical School Steven...
Hoagland (1921–2009), US physician and biochemist, co-discovered tRNA with PaulZamecnik Dorothy Hodgkin (1910–1994), British pioneer of protein crystallography...
train. David Shepherd, 68, British cricketer and umpire, lung cancer. PaulZamecnik, 96, American molecular biologist. Olga Kevelos, 85, British motorcycle...
Hanover chapter of AA offers guidance to undergrads". The Dartmouth. "Zamecnik Timeline". Lasker Foundation. Archived from the original on October 26...
mathematician, author of several financial models including Vasicek model. PaulZamecnik, of Czech ancestry, a biochemist of note, who played a central role...
in nature was already discovered by the team of Mahlon Hoagland and PaulZamecnik, whose paper was published the following year in March 1958. These “soluble...
November 21 – Eleanor Powell, film tap dancer (died 1982) November 22 – PaulZamecnik, molecular biologist (died 2009) November 23 George O'Hanlon, film and...
Williams (d.) Marjorie P. Wilson (d.) Geraldine Pittman Woods (d.) PaulZamecnik (d.) Faye Glenn Abdellah (d.) Lewis M. Branscomb Lester Breslow (d.)...
graduation, he worked as a postdoctoral fellow at Harvard University with PaulZamecnik, who was then one of a very small number of researchers studying the...
Ponseti, Menorcan-born pediatric orthopedist (b. 1914). 27 October – PaulZamecnik, American scientist who played a central role in the early history of...
org. April 2020. Retrieved 11 November 2020. "Nomination Archive – P C Zamecnik". NobelPrize.org. April 2020. Retrieved 11 November 2020. "Nomination Archive...
a research position at Massachusetts General Hospital in the lab of PaulZamecnik, where he researched and detailed the role of transfer RNA in forming...
1972 Kimishige Ishizaka, Teruko Ishizaka 1971 Stephen W. Kuffler 1970 PaulZamecnik 1969 George Herbert Hitchings (1988 Nobel Prize in Physiology or Medicine)...
transcriber of the piece. It also bears a resemblance to part of John Stepan Zamecnik's 1913 composition Mysterious – Burglar Music 1, which appeared in Sam Fox...
Massachusetts Institute of Technology (1949-1960). Her collaboration with PaulZamecnik included several studies that investigated the incorporation of labeled...
Trades magazine in the late 1910s, made by American composer John Stepan Zamecnik. The 1960s saw contracts with six-figures such as an advance deal for $143...
246S–8S. doi:10.1093/ajcn/55.1.246s. PMID 1345887. Bell, D. G.; Jacobs, I.; Zamecnik, J. (April 1998). "Effects of caffeine, ephedrine and their combination...
Lincoln. New York: Hurd and Houghton. ISBN 1-58218-120-9. Cielontko, D. and Zámečník J. (2023). When you do not fit in: Ugliness as a Theological Problem."...
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