Pathogen reduction using riboflavin and UV light information
Pathogen reduction using riboflavin and UV light is a method by which infectious pathogens in blood for transfusion are inactivated by adding riboflavin and irradiating with UV light.[1][2][3] This method reduces the infectious levels of disease-causing agents that may be found in donated blood components, while still maintaining good quality blood components for transfusion. This type of approach to increase blood safety is also known as “pathogen inactivation” in the industry.
Despite measures that are in place in the developed world to ensure the safety of blood products for transfusion, a risk of disease transmission still exists. Consequently, the development of pathogen inactivation/reduction technologies for blood products has been an ongoing effort in the field of transfusion medicine. A new procedure for the treatment of individual units of single-donor (apheresis) or whole blood–derived, pooled, platelets has recently been introduced. This technology uses riboflavin and light for the treatment of platelets and plasma.
^Hardwick CC, Herivel TR, Hernandez SC, Ruane PH, Goodrich RP (2004). "Separation, identification and quantification of riboflavin and its photoproducts in blood products using high-performance liquid chromatography with fluorescence detection: a method to support pathogen reduction technology". Photochem. Photobiol. 80 (3): 609–15. doi:10.1562/0031-8655(2004)080<0609:TNSIAQ>2.0.CO;2. ISSN 0031-8655. PMID 15382964. S2CID 198154059.
^Sullivan J, et al. (2008). "Pathogen Inactivation of plasmodium Falciparum in Plasma and Platelet Concentrations with Riboflavin and UV Light". Vox Sanguinis. 95 (Suppl. 1): 278–279. doi:10.1111/j.1423-0410.2008.01056.x. hdl:10292/2147.
^Reddy HL, Dayan AD, Cavagnaro J, Gad S, Li J, Goodrich RP (April 2008). "Toxicity testing of a novel riboflavin-based technology for pathogen reduction and white blood cell inactivation". Transfus Med Rev. 22 (2): 133–53. doi:10.1016/j.tmrv.2007.12.003. PMID 18353253.
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