Parramatta River virus (PaRV) is an insect virus belonging to Flaviviridae and endemic to Australia. It was discovered in 2015.[1] The virus was identified from the mosquito Aedes vigilax collected from Sydney under the joint research project by scientists at the University of Queensland and the University of Sydney. In experimental infections, the virus is unable to grow in vertebrate cells, but only in Aedes-derived mosquito cell lines. This suggests that the virus does not infect vertebrates. The name is given because it was discovered from Silverwater, a suburb of Sydney on the southern bank of the Parramatta River. The mosquitoes from which the virus was isolated were actually collected in 2007, and had been preserved since then. The study commenced only after the development of the technique of viral detection in mosquitoes in the University of Queensland.[2]
The virus was identified as a result of investigation on the outbreak of Ross River virus in 2015. Both the viruses are transmitted by the same mosquitoes, but PaRV is not transmitted to humans, unlike RRV. According to one of the co-authors, Cameron Webb of the University of Sydney, this unique transmission of PaRV could hold a key "to vaccinate mosquitoes and stop their bites making thousands of Australians sick every summer."[3] The reason, explained by Jody Hobson-Peters of the University of Queensland, is that if mosquitoes (vectors for human diseases) are infected with the PaRV, then they will no longer be able to carry other human-infectious viruses.[4]
The virus was identified from the whole genome sequence using Sanger sequencing. The viral genome consists of 10,893 nucleotides and encodes a polyprotein of 3384 amino acids. Comparison with the genomes of other viruses showed that its closest relatives are the Mediterranean Ochlerotatus flavivirus (MoFV) isolated from Ochlerotatus mosquitoes in Spain, and the Hanko virus (HANKV) from Ochlerotatus mosquitoes in Finland (both identified in 2012[5][6]). With MoFV its shares 72.7% nucleotide identity, and with HANKV the nucleotide similarity is 71.4%.[1]
The complete structure of the 3'UTR RNA of PaRV has been solved, revealing that that PaRV has evolved to produce multiple separate sfRNAs from its 3'UTR.[7] Duplicated xrRNAs in PaRV and other insect-specific Flaviviruses appear to be evolutionarily selected for to provide functional redundancy allowing the production of sfRNAs if one structures is disabled by mutations.[7]
^ abMcLean, Breeanna J.; Hobson-Peters, Jody; Webb, Cameron E.; Watterson, Daniel; Prow, Natalie A.; Nguyen, Hong Duyen; Hall-Mendelin, Sonja; Warrilow, David; Johansen, Cheryl A.; Jansen, Cassie C.; van den Hurk, Andrew F.; Beebe, Nigel W.; Schnettler, Esther; Barnard, Ross T.; Hall, Roy A. (2015). "A novel insect-specific flavivirus replicates only in Aedes-derived cells and persists at high prevalence in wild Aedes vigilax populations in Sydney, Australia". Virology. 486: 272–283. doi:10.1016/j.virol.2015.07.021. PMID 26519596.
^Morris, Cathy (9 December 2015). "Scientists discover Parramatta River virus". The Daily Telegraph. Retrieved 21 September 2016.
^"'Good' mozzie virus might hold key to fighting human disease". www.sciencedaily.com. 17 November 2015. Retrieved 22 September 2016.
^Rigby, Mark; Staley, Phil (18 November 2015). "'Good' mosquito virus could be key to eradicating mosquito-borne diseases in humans". Retrieved 22 September 2016.
^Vázquez, Ana; Sánchez-Seco, María-Paz; Palacios, Gustavo; Molero, Francisca; Reyes, Noelia; Ruiz, Santiago; Aranda, Carles; Marqués, Eduard; Escosa, Raul; Moreno, Juana; Figuerola, Jordi; Tenorio, Antonio (2012). "Novel Flaviviruses Detected in Different Species of Mosquitoes in Spain" (PDF). Vector-Borne and Zoonotic Diseases. 12 (3): 223–229. doi:10.1089/vbz.2011.0687. PMC 3300060. PMID 22022811.
ParramattaRivervirus (PaRV) is an insect virus belonging to Flaviviridae and endemic to Australia. It was discovered in 2015. The virus was identified...
(ISFs) such as cell fusing agent virus (CFAV), Palm Creek virus (PCV), and ParramattaRivervirus (PaRV). While dual-host flaviviruses can infect vertebrates...
final that year was played between the Parramatta Eels and once again Melbourne Storm. Melbourne defeated Parramatta 23 – 16 to win the premiership to make...
Appin in the south to the Hawkesbury River in the north; west of the Georges River, Parramatta, the Lane Cove River and Berowra Creek". R. H. Mathews (1903)...
timber. He was the artistic director of the Pros and Cons Playhouse at Parramatta Gaol from 1979 to 1981, and established the drama service on Kiribati...
Campbelltown, Canterbury-Bankstown, Cumberland, Fairfield, Georges River, Liverpool, Parramatta, Strathfield, and parts of Penrith, from 9:00 pm to 5:00 am (AEST)...
and a replenishment oiler. Australia responded by sending Stuart and Parramatta, as well as a P-3 Orion surveillance plane, to monitor the Russians. Although...
Rugby League season for 2020 restarted after the COVID-19 hiatus with the Parramatta Eels defeating the Brisbane Broncos; The National Rugby League announced...
Thomas Chipp: marine private per Friendship died 3 July 1842, buried Parramatta, aged 81 (NSW Reg age 93). Anthony Rope: convict per Alexander died 20...
the Sydney region, and particularly abundant between the localities of Parramatta and Penrith. It dramatically declined in numbers between 1875 and 1895...
Brownlie eventually signed for Parramatta Power when contract negotiations with Perth Glory broke down. Despite Parramatta finishing third, Brownlie had...
original Camellia Grove nursery on the ParramattaRiver in the 1850s. See Barker, Geoff (14 May 2014). "The ParramattaRiver 1848 to 1861 – Personal Observations...
drawn from the Botany Swamps with no filtration or treatment, while Parramatta's supply also lacked these advantages. The Walka scheme's nearest rival...
— The ARL competition kicks off with the Parramatta Eels defeating the North Sydney Bears 10–8 at Parramatta Stadium. 19 May — In the one and only Super...
Australia. For services to local government. Francis Michael Quealey, of Parramatta, State of New South Wales. For public services. Sister Mary Clare Richardson...
premiership following the final main round of the 2018 NRL season. The Parramatta Eels finish in last position, claiming the wooden spoon. 24 September...
exceptional service in warlike operations as the Commanding Officer HMAS PARRAMATTA in the Northern Arabian Gulf during Operation CATALYST. Commodore Les...