PTPN5 information

PTPN5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2BIJ, 2BV5, 2CJZ
Identifiers
Aliases	PTPN5, PTPSTEP, STEP, STEP61, protein tyrosine phosphatase, non-receptor type 5, protein tyrosine phosphatase non-receptor type 5
External IDs	OMIM: 176879; MGI: 97807; HomoloGene: 8423; GeneCards: PTPN5; OMA:PTPN5 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	18,792,721 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	46,783,432 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; middle temporal gyrus; ; Brodmann area 23; ; nucleus accumbens; ; putamen; ; primary visual cortex; ; caudate nucleus; ; external globus pallidus; ; superior frontal gyrus; ; postcentral gyrus;
	Top expressed in
	olfactory tubercle; ; superior frontal gyrus; ; nucleus accumbens; ; lateral septal nucleus; ; globus pallidus; ; primary visual cortex; ; anterior amygdaloid area; ; nucleus of stria terminalis; ; medial dorsal nucleus; ; lateral geniculate nucleus;
	More reference expression data
	n/a
Gene ontology
Molecular function	phosphoprotein phosphatase activity; phosphatase activity; phosphotyrosine residue binding; protein binding; protein tyrosine phosphatase activity; hydrolase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; membrane; endoplasmic reticulum; nucleoplasm;
Biological process	protein dephosphorylation; peptidyl-tyrosine dephosphorylation; dephosphorylation; cellular response to cytokine stimulus;
	Sources:Amigo / QuickGO
Orthologs
	84867
	19259
	ENSG00000110786
	ENSMUSG00000030854
	P54829
	P54830
NM_001039970; NM_001278236; NM_001278238; NM_001278239; NM_006906;
	NM_032781
	NM_001163565; NM_013643
NP_001035059; NP_001265165; NP_001265167; NP_001265168; NP_008837;
	NP_116170
	NP_001157037; NP_038671
	Wikidata
View/Edit Human	View/Edit Mouse

Protein tyrosine phosphatase non-receptor type 5 is an enzyme that in humans is encoded by the PTPN5 gene.^[5]^[6]

Protein tyrosine phosphatase (PTP), non-receptor type 5, also known as STEP (STriatal-Enriched protein tyrosine Phosphatase), was the first brain-specific PTP discovered.^[5] The human STEP locus maps to chromosome 11p15.2-p15.1 and the murine STEP gene to chromosome 7B3-B5.^[7] The single STEP gene is alternatively spliced to produce several isoforms,^[8]^[9] the best characterized of which are the cytosolic STEP₄₆ protein and the membrane-associated STEP₆₁ protein.^[10]^[11]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000110786 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000030854 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b Lombroso PJ, Murdoch G, Lerner M (Aug 1991). "Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum". Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 7242–6. Bibcode:1991PNAS...88.7242L. doi:10.1073/pnas.88.16.7242. PMC 52270. PMID 1714595.
^ "Entrez Gene: PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)".
^ Li X, Luna J, Lombroso PJ, Francke U (Aug 1995). "Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci". Genomics. 28 (3): 442–9. doi:10.1006/geno.1995.1173. PMID 7490079.
^ Sharma E, Zhao F, Bult A, Lombroso PJ (Aug 1995). "Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases". Brain Research. Molecular Brain Research. 32 (1): 87–93. doi:10.1016/0169-328x(95)00066-2. PMID 7494467.
^ Bult A, Zhao F, Dirkx R, Sharma E, Lukacsi E, Solimena M, Naegele JR, Lombroso PJ (Dec 1996). "STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum". The Journal of Neuroscience. 16 (24): 7821–31. doi:10.1523/JNEUROSCI.16-24-07821.1996. PMC 6579237. PMID 8987810.
^ Lombroso PJ, Naegele JR, Sharma E, Lerner M (Jul 1993). "A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures". The Journal of Neuroscience. 13 (7): 3064–74. doi:10.1523/JNEUROSCI.13-07-03064.1993. PMC 6576687. PMID 8331384.
^ Boulanger LM, Lombroso PJ, Raghunathan A, During MJ, Wahle P, Naegele JR (Feb 1995). "Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase". The Journal of Neuroscience. 15 (2): 1532–44. doi:10.1523/JNEUROSCI.15-02-01532.1995. PMC 6577844. PMID 7869116.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000110786 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000030854 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1714595-5] Lombroso PJ, Murdoch G, Lerner M (Aug 1991). "Molecular characterization of a protein-tyrosine-phosphatase enriched in striatum". Proceedings of the National Academy of Sciences of the United States of America. 88 (16): 7242–6. Bibcode:1991PNAS...88.7242L. doi:10.1073/pnas.88.16.7242. PMC 52270. PMID 1714595.

[entrez-6] "Entrez Gene: PTPN5 protein tyrosine phosphatase, non-receptor type 5 (striatum-enriched)".

[7] Li X, Luna J, Lombroso PJ, Francke U (Aug 1995). "Molecular cloning of the human homolog of a striatum-enriched phosphatase (STEP) gene and chromosomal mapping of the human and murine loci". Genomics. 28 (3): 442–9. doi:10.1006/geno.1995.1173. PMID 7490079.

[8] Sharma E, Zhao F, Bult A, Lombroso PJ (Aug 1995). "Identification of two alternatively spliced transcripts of STEP: a subfamily of brain-enriched protein tyrosine phosphatases". Brain Research. Molecular Brain Research. 32 (1): 87–93. doi:10.1016/0169-328x(95)00066-2. PMID 7494467.

[9] Bult A, Zhao F, Dirkx R, Sharma E, Lukacsi E, Solimena M, Naegele JR, Lombroso PJ (Dec 1996). "STEP61: a member of a family of brain-enriched PTPs is localized to the endoplasmic reticulum". The Journal of Neuroscience. 16 (24): 7821–31. doi:10.1523/JNEUROSCI.16-24-07821.1996. PMC 6579237. PMID 8987810.

[10] Lombroso PJ, Naegele JR, Sharma E, Lerner M (Jul 1993). "A protein tyrosine phosphatase expressed within dopaminoceptive neurons of the basal ganglia and related structures". The Journal of Neuroscience. 13 (7): 3064–74. doi:10.1523/JNEUROSCI.13-07-03064.1993. PMC 6576687. PMID 8331384.

[11] Boulanger LM, Lombroso PJ, Raghunathan A, During MJ, Wahle P, Naegele JR (Feb 1995). "Cellular and molecular characterization of a brain-enriched protein tyrosine phosphatase". The Journal of Neuroscience. 15 (2): 1532–44. doi:10.1523/JNEUROSCI.15-02-01532.1995. PMC 6577844. PMID 7869116.

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