cyclin-dependent protein serine/threonine kinase activity
RNA binding
Cellular component
catalytic step 2 spliceosome
spliceosomal complex
nucleus
chromosome
nuclear speck
Biological process
mRNA splicing, via spliceosome
protein phosphorylation
mRNA processing
RNA splicing
phosphorylation
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
8899
19134
Ensembl
ENSG00000112739
ENSMUSG00000021413
UniProt
Q13523
Q61136
RefSeq (mRNA)
NM_003913 NM_176800
NM_013830
RefSeq (protein)
NP_003904
NP_038858
Location (UCSC)
Chr 6: 4.02 – 4.06 Mb
Chr 13: 34.88 – 34.91 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[5][6][7]
Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).[7]
^ abcGRCh38: Ensembl release 89: ENSG00000112739 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000021413 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
^Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.
Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene. Pre-mRNA splicing occurs in two sequential transesterification steps...