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PRPF4B information


PRPF4B
Available structures
PDBOrtholog search: PDBe RCSB
Identifiers
AliasesPRPF4B, PR4H, PRP4, PRP4H, PRP4K, dJ1013A10.1, pre-mRNA processing factor 4B
External IDsOMIM: 602338; MGI: 109584; HomoloGene: 134085; GeneCards: PRPF4B; OMA:PRPF4B - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_003913
NM_176800

NM_013830

RefSeq (protein)

NP_003904

NP_038858

Location (UCSC)Chr 6: 4.02 – 4.06 MbChr 13: 34.88 – 34.91 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene.[5][6][7]

Pre-mRNA splicing occurs in two sequential transesterification steps, and the protein encoded by this gene is thought to be involved in pre-mRNA splicing and in signal transduction. This protein belongs to a kinase family that includes serine/arginine-rich protein-specific kinases and cyclin-dependent kinases (CDKs). This protein is regarded as a CDK-like kinase (Clk) with homology to mitogen-activated protein kinases (MAPKs).[7]

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000112739 – Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000021413 – Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ^ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
  6. ^ Kojima T, Zama T, Wada K, Onogi H, Hagiwara M (Aug 2001). "Cloning of human PRP4 reveals interaction with Clk1". J Biol Chem. 276 (34): 32247–56. doi:10.1074/jbc.M103790200. PMID 11418604.
  7. ^ a b "Entrez Gene: PRPF4B PRP4 pre-mRNA processing factor 4 homolog B (yeast)".

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PRPF4B

Last Update:

Serine/threonine-protein kinase PRP4 homolog is an enzyme that in humans is encoded by the PRPF4B gene. Pre-mRNA splicing occurs in two sequential transesterification steps...

Word Count : 995

Protein kinase domain

Last Update:

PRKCI ; PRKCQ ; PRKCZ ; PRKD1 ; PRKD2 ; PRKD3 ; PRKG1 ; PRKG2 ; PRKX ; PRKY ; PRPF4B ; PSKH1 ; PSKH2 ; PTK2 ; PTK2B ; PTK6 ; PTK7 ; PXK ; RAF1 ; RET ; RIOK1 ;...

Word Count : 1559

Pinin

Last Update:

shown to interact with Keratin 8, Keratin 18, Keratin 19, CTBP1, RNPS1, PRPF4B, SFRS4, PPIG, SRRM2 and SFRS18. GRCh38: Ensembl release 89: ENSG00000100941...

Word Count : 1373

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