PRAME information

PRAME
Identifiers
Aliases	PRAME, CT130, MAPE, OIP-4, OIP4, preferentially expressed antigen in melanoma, PRAME nuclear receptor transcriptional regulator
External IDs	OMIM: 606021 HomoloGene: 48404 GeneCards: PRAME
Gene location (Human)
Chr.	Chromosome 22 (human)
End	22,559,361 bp
RNA expression pattern
	Top expressed in
	endometrium; ; left adrenal gland; ; kidney; ; renal cortex; ; appendix; ; smooth muscle tissue; ; lymph node; ; gastrocnemius muscle; ; uterine tube; ; left uterine tube;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; retinoic acid receptor binding;
Cellular component	plasma membrane; nucleus; membrane; cytoplasm;
Biological process	negative regulation of cell differentiation; regulation of growth; cell differentiation; negative regulation of apoptotic process; negative regulation of transcription, DNA-templated; regulation of transcription, DNA-templated; transcription, DNA-templated; positive regulation of cell population proliferation; apoptotic process; negative regulation of retinoic acid receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	23532
	n/a
	ENSG00000185686; ENSG00000275013
	n/a
	P78395
	n/a
NM_001291715; NM_001291716; NM_001291717; NM_001291719; NM_006115;
	NM_206953; NM_206954; NM_206955; NM_206956; NM_001318126; NM_001318127
	n/a
NP_001278644; NP_001278645; NP_001278646; NP_001278648; NP_001305055;
	NP_001305056; NP_006106; NP_996836; NP_996837; NP_996838; NP_996839
	n/a
	Wikidata
View/Edit Human

PRAME (preferentially expressed antigen of melanoma) is a protein that in humans is encoded by the PRAME gene.^[3]^[4]^[5] Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.^[5]

^ ^a ^b ^c ENSG00000275013 GRCh38: Ensembl release 89: ENSG00000185686, ENSG00000275013 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Ikeda H, Lethé B, Lehmann F, van Baren N, Baurain JF, de Smet C, Chambost H, Vitale M, Moretta A, Boon T, Coulie PG (Feb 1997). "Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor". Immunity. 6 (2): 199–208. doi:10.1016/S1074-7613(00)80426-4. PMID 9047241.
^ Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.
^ ^a ^b "Entrez Gene: PRAME preferentially expressed antigen in melanoma".

[refGRCh38Ensembl-1] ENSG00000275013 GRCh38: Ensembl release 89: ENSG00000185686, ENSG00000275013 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9047241-3] Ikeda H, Lethé B, Lehmann F, van Baren N, Baurain JF, de Smet C, Chambost H, Vitale M, Moretta A, Boon T, Coulie PG (Feb 1997). "Characterization of an antigen that is recognized on a melanoma showing partial HLA loss by CTL expressing an NK inhibitory receptor". Immunity. 6 (2): 199–208. doi:10.1016/S1074-7613(00)80426-4. PMID 9047241.

[pmid10591208-4] Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP (Dec 1999). "The DNA sequence of human chromosome 22". Nature. 402 (6761): 489–95. Bibcode:1999Natur.402..489D. doi:10.1038/990031. PMID 10591208.

[entrez-5] "Entrez Gene: PRAME preferentially expressed antigen in melanoma".

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