dentate gyrus of hippocampal formation granule cell
superior frontal gyrus
cerebellar cortex
primary visual cortex
lateral hypothalamus
lateral geniculate nucleus
hippocampus proper
More reference expression data
BioGPS
More reference expression data
Gene ontology
Molecular function
phosphomannomutase activity
isomerase activity
protein binding
metal ion binding
Cellular component
cytoplasm
neuronal cell body
cytosol
Biological process
mannose metabolic process
protein N-linked glycosylation
protein targeting to ER
GDP-mannose biosynthetic process
cellular response to leukemia inhibitory factor
Sources:Amigo / QuickGO
Orthologs
Species
Human
Mouse
Entrez
5372
29858
Ensembl
ENSG00000100417
ENSMUSG00000022474
UniProt
Q92871
O35621
RefSeq (mRNA)
NM_002676
NM_001282040 NM_001282041 NM_013872
RefSeq (protein)
NP_002667
NP_001268969 NP_001268970 NP_038900
Location (UCSC)
Chr 22: 41.58 – 41.59 Mb
Chr 15: 81.84 – 81.85 Mb
PubMed search
[3]
[4]
Wikidata
View/Edit Human
View/Edit Mouse
Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene.[5][6][7]
Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate and D-mannose 1-phosphate which is a substrate for GDP-mannose synthesis. GDP-mannose is used for synthesis of dolichol-phosphate-mannose, which is essential for N-linked glycosylation and thus the secretion of several glycoproteins as well as for the synthesis of Glycosylphosphatidylinositol (GPI) anchored proteins.[7]
This enzyme has been extracted from the venom of the wasp species Polistes major major.[8]
^ abcGRCh38: Ensembl release 89: ENSG00000100417 – Ensembl, May 2017
^ abcGRCm38: Ensembl release 89: ENSMUSG00000022474 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Matthijs G, Schollen E, Pirard M, Budarf ML, Van Schaftingen E, Cassiman JJ (Jun 1997). "PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized on chromosome 22q13". Genomics. 40 (1): 41–7. doi:10.1006/geno.1996.4536. PMID 9070917.
^Pirard M, Collet JF, Matthijs G, Van Schaftingen E (Sep 1997). "Comparison of PMM1 with the phosphomannomutases expressed in rat liver and in human cells". FEBS Lett. 411 (2–3): 251–4. doi:10.1016/S0014-5793(97)00704-7. PMID 9271215.
^ ab"Entrez Gene: PMM1 phosphomannomutase 1".
^ČeŘovský V (2007). "Identification of three novel peptides isolated from the venom of the neotropical social wasp Polistes major major". Journal of Peptide Science. 13 (7): 445–450. doi:10.1002/psc.860. PMID 17559065. S2CID 41958134.
Phosphomannomutase 1 is an enzyme that in humans is encoded by the PMM1 gene. Phosphomannomutase catalyzes the conversion between D-mannose 6-phosphate...
namely the red-bellied woodpecker (Melanerpes carolinus). Three peptides, PMM1, PMM2, and PMM3 have been extracted and identified from the venom of Polistes...
Pirard M, Budarf ML, Van Schaftingen E, Cassiman JJ (February 1997). "PMM (PMM1), the human homologue of SEC53 or yeast phosphomannomutase, is localized...