PLXNA4A information

PLXNA4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4E74
Identifiers
Aliases	PLXNA4, FAYV2820, PLEXA4, PLXNA4A, PLXNA4B, PRO34003, plexin A4
External IDs	OMIM: 604280; MGI: 2179061; HomoloGene: 77587; GeneCards: PLXNA4; OMA:PLXNA4 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	132,648,688 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	32,565,127 bp
RNA expression pattern
	Top expressed in
	oocyte; ; ganglionic eminence; ; pons; ; Brodmann area 23; ; postcentral gyrus; ; middle temporal gyrus; ; superior frontal gyrus; ; entorhinal cortex; ; adipose tissue; ; occipital lobe;
	Top expressed in
	superior cervical ganglion; ; dentate gyrus; ; molar; ; ganglionic eminence; ; parasympathetic nervous system; ; piriform cortex; ; secondary oocyte; ; subiculum; ; primary motor cortex; ; olfactory tubercle;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	semaphorin receptor activity;
Cellular component	integral component of membrane; membrane; plasma membrane; semaphorin receptor complex; integral component of plasma membrane;
Biological process	glossopharyngeal nerve morphogenesis; neuron projection morphogenesis; regulation of axon extension involved in axon guidance; cranial nerve morphogenesis; sympathetic nervous system development; vagus nerve morphogenesis; trigeminal nerve morphogenesis; nervous system development; anterior commissure morphogenesis; postganglionic parasympathetic fiber development; branchiomotor neuron axon guidance; regulation of negative chemotaxis; facial nerve structural organization; motor neuron axon guidance; trigeminal nerve structural organization; semaphorin-plexin signaling pathway; chemorepulsion of branchiomotor axon; signal transduction; facial nerve morphogenesis; axon guidance; semaphorin-plexin signaling pathway involved in axon guidance; negative regulation of cell adhesion; regulation of cell shape; regulation of cell migration; regulation of GTPase activity; positive regulation of axonogenesis;
	Sources:Amigo / QuickGO
Orthologs
	91584
	243743
	ENSG00000221866
	ENSMUSG00000029765
	Q9HCM2
	Q80UG2
	NM_001105543; NM_020911; NM_181775; NM_001393897
	NM_175750
	NP_001099013; NP_065962; NP_861440
	NP_786926
	Wikidata
View/Edit Human	View/Edit Mouse

Plexin-A4 is a protein that in humans is encoded by the PLXNA4 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000221866 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029765 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (October 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000221866 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029765 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10520995-5] Tamagnone L, Artigiani S, Chen H, He Z, Ming GI, Song H, Chedotal A, Winberg ML, Goodman CS, Poo M, Tessier-Lavigne M, Comoglio PM (October 1999). "Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates". Cell. 99 (1): 71–80. doi:10.1016/S0092-8674(00)80063-X. PMID 10520995. S2CID 17386412.