PIWIL1 information

PIWIL1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2L5C, 2L5D, 3O3I, 3O6E, 3O7V
Identifiers
Aliases	PIWIL1, CT80.1, HIWI, MIWI, PIWI, piwi like RNA-mediated gene silencing 1
External IDs	OMIM: 605571; MGI: 1928897; HomoloGene: 37963; GeneCards: PIWIL1; OMA:PIWIL1 - orthologs
Gene location (Human)
Chr.	Chromosome 12 (human)
End	130,372,637 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	128,832,538 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; right lobe of thyroid gland; ; right uterine tube; ; canal of the cervix; ; spleen; ; superior frontal gyrus; ; kidney; ; left lobe of thyroid gland; ; endometrium; ; rectum;
	Top expressed in
	spermatocyte; ; seminiferous tubule; ; secondary oocyte; ; spermatid; ; female urethra; ; ovary; ; islet of Langerhans; ; hypothalamus; ; urinary bladder;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein kinase binding; RNA binding; single-stranded RNA binding; nucleic acid binding; protein binding; mRNA binding; nuclease activity; endonuclease activity; endoribonuclease activity; hydrolase activity; metal ion binding; piRNA binding; protein-containing complex binding; polysome binding; mRNA cap binding complex binding;
Cellular component	polysome; nucleus; mRNA cap binding complex; dense body; P granule; cytoplasm; chromatoid body;
Biological process	multicellular organism development; regulation of translation; meiosis; cell differentiation; gene silencing; spermatogenesis; negative regulation of transposition; piRNA metabolic process; nucleic acid phosphodiester bond hydrolysis; RNA phosphodiester bond hydrolysis, endonucleolytic; spermatid development;
	Sources:Amigo / QuickGO
Orthologs
	9271
	57749
	ENSG00000275051; ENSG00000125207
	ENSMUSG00000029423
	Q96J94
	Q9JMB7
	NM_001190971; NM_004764
	NM_021311
	NP_001177900; NP_004755
	NP_067286
	Wikidata
View/Edit Human	View/Edit Mouse

Piwi-like protein 1 is a protein that in humans is encoded by the PIWIL1 gene.^[5]^[6]^[7]

This gene encodes a member of the PIWI subfamily of Argonaute proteins, evolutionarily conserved proteins containing both PAZ and Piwi motifs that play important roles in stem cell self-renewal, RNA silencing, and translational regulation in diverse organisms.

The encoded protein may play a role as an intrinsic regulator of the self-renewal capacity of germline and hematopoietic stem cells.^[7]

^ ^a ^b ^c ENSG00000125207 GRCh38: Ensembl release 89: ENSG00000275051, ENSG00000125207 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000029423 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H (Jan 1999). "A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal". Genes Dev. 12 (23): 3715–27. doi:10.1101/gad.12.23.3715. PMC 317255. PMID 9851978.
^ Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.
^ ^a ^b "Entrez Gene: PIWIL1 piwi-like 1 (Drosophila)".

[refGRCh38Ensembl-1] ENSG00000125207 GRCh38: Ensembl release 89: ENSG00000275051, ENSG00000125207 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000029423 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9851978-5] Cox DN, Chao A, Baker J, Chang L, Qiao D, Lin H (Jan 1999). "A novel class of evolutionarily conserved genes defined by piwi are essential for stem cell self-renewal". Genes Dev. 12 (23): 3715–27. doi:10.1101/gad.12.23.3715. PMC 317255. PMID 9851978.

[pmid12906857-6] Sasaki T, Shiohama A, Minoshima S, Shimizu N (Aug 2003). "Identification of eight members of the Argonaute family in the human genome small star, filled". Genomics. 82 (3): 323–30. doi:10.1016/S0888-7543(03)00129-0. PMID 12906857.

[entrez-7] "Entrez Gene: PIWIL1 piwi-like 1 (Drosophila)".

PIWIL1 information

and 4 Related for: PIWIL1 information

PIWIL1

Chromosome 12

Tudor domain

Haifan Lin