PIGB information

PIGB
Identifiers
Aliases	PIGB, GPI-MT-III, PIG-B, phosphatidylinositol glycan anchor biosynthesis class B, EIEE80, DEE80
External IDs	OMIM: 604122; MGI: 1891825; HomoloGene: 3570; GeneCards: PIGB; OMA:PIGB - orthologs
Gene location (Human)
Chr.	Chromosome 15 (human)
End	55,355,648 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	72,947,660 bp
RNA expression pattern
	Top expressed in
	granulocyte; ; blood; ; Achilles tendon; ; monocyte; ; anterior pituitary; ; left lobe of thyroid gland; ; right lobe of thyroid gland; ; body of pancreas; ; gastric mucosa; ; spleen;
	Top expressed in
	ascending aorta; ; aortic valve; ; granulocyte; ; tail of embryo; ; genital tubercle; ; neural layer of retina; ; dentate gyrus of hippocampal formation granule cell; ; supraoptic nucleus; ; right kidney; ; zygote;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transferase activity; mannosyltransferase activity; glycosyltransferase activity; glycolipid mannosyltransferase activity;
Cellular component	integral component of membrane; endoplasmic reticulum membrane; endoplasmic reticulum; membrane;
Biological process	GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane; mannosylation;
	Sources:Amigo / QuickGO
Orthologs
	9488
	55981
	ENSG00000069943
	ENSMUSG00000079469
	Q92521
	Q9JJQ0
	NM_004855
	NM_018889
	NP_004846
	NP_061377
	Wikidata
View/Edit Human	View/Edit Mouse

GPI mannosyltransferase 3 is an enzyme that in humans is encoded by the PIGB gene.^[5]^[6]

This gene encodes a transmembrane protein that is located in the endoplasmic reticulum and is involved in GPI-anchor biosynthesis. The glycosylphosphatidylinositol (GPI) anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene is thought to encode a member of a family of dolichol-phosphate-mannose (Dol-P-Man) dependent mannosyltransferases.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000069943 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000079469 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Takahashi M, Inoue N, Ohishi K, Maeda Y, Nakamura N, Endo Y, Fujita T, Takeda J, Kinoshita T (Dec 1996). "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor". EMBO J. 15 (16): 4254–61. doi:10.1002/j.1460-2075.1996.tb00800.x. PMC 452151. PMID 8861954.
^ ^a ^b "Entrez Gene: PIGB phosphatidylinositol glycan anchor biosynthesis, class B".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000069943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000079469 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8861954-5] Takahashi M, Inoue N, Ohishi K, Maeda Y, Nakamura N, Endo Y, Fujita T, Takeda J, Kinoshita T (Dec 1996). "PIG-B, a membrane protein of the endoplasmic reticulum with a large lumenal domain, is involved in transferring the third mannose of the GPI anchor". EMBO J. 15 (16): 4254–61. doi:10.1002/j.1460-2075.1996.tb00800.x. PMC 452151. PMID 8861954.

[entrez-6] "Entrez Gene: PIGB phosphatidylinositol glycan anchor biosynthesis, class B".

PIGB information

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