PHF8 information

PHF8
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4DO0, 3K3O, 2WWU, 3K3N, 3KV4,%%s2WWU, 3K3N, 3K3O, 3KV4, 4DO0
Identifiers
Aliases	PHF8, JHDM1F, MRXSSD, ZNF422, PHD finger protein 8, KDM7B
External IDs	OMIM: 300560; MGI: 2444341; HomoloGene: 49405; GeneCards: PHF8; OMA:PHF8 - orthologs
Gene location (Human)
Chr.	X chromosome (human)
End	54,048,958 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	150,416,855 bp
RNA expression pattern
	Top expressed in
	right testis; ; sural nerve; ; left testis; ; testicle; ; tendon of biceps brachii; ; Achilles tendon; ; epithelium of colon; ; right lobe of liver; ; gonad; ; right uterine tube;
	Top expressed in
	zygote; ; primary oocyte; ; otic vesicle; ; saccule; ; blood; ; secondary oocyte; ; otic placode; ; Gonadal ridge; ; granulocyte; ; medial ganglionic eminence;
	More reference expression data
	n/a
Gene ontology
Molecular function	2-oxoglutarate-dependent dioxygenase activity; iron ion binding; histone H3-methyl-lysine-9 demethylase activity; histone H4-methyl-lysine-20 demethylase activity; chromatin binding; dioxygenase activity; metal ion binding; methylated histone binding; protein binding; histone H3-methyl-lysine-36 demethylase activity; oxidoreductase activity; histone H3-tri/di-methyl-lysine-27 demethylase activity; histone demethylase activity; zinc ion binding;
Cellular component	nuclear membrane; nucleoplasm; nucleolus; nucleus;
Biological process	regulation of transcription, DNA-templated; histone H3-K27 demethylation; histone H3-K9 demethylation; histone H4-K20 demethylation; transcription, DNA-templated; positive regulation of transcription, DNA-templated; brain development; negative regulation of ribosomal DNA heterochromatin assembly; histone H3-K36 demethylation; cell cycle; positive regulation of transcription by RNA polymerase I; G1/S transition of mitotic cell cycle; chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	23133
	320595
	ENSG00000172943
	ENSMUSG00000041229
	Q9UPP1
	Q80TJ7
	NM_001184896; NM_001184897; NM_001184898; NM_015107
	NM_001113354; NM_177201
	NP_001171825; NP_001171826; NP_001171827; NP_055922
	NP_001106825; NP_796175
	Wikidata
View/Edit Human	View/Edit Mouse

PHD finger protein 8 is a protein that in humans is encoded by the PHF8 gene.^[5]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000172943 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000041229 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Entrez Gene: PHF8 PHD finger protein 8".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000172943 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000041229 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PHF8 PHD finger protein 8".

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