Prostate cancer antigen 3 (PCA3, also referred to as DD3) is a gene that expresses a non-coding RNA. PCA3 is only expressed in human prostate tissue, and the gene is highly overexpressed in prostate cancer.[3][4] Because of its restricted expression profile, the PCA3 RNA is useful as a tumor marker.[5]
^ abcGRCh38: Ensembl release 89: ENSG00000225937 – Ensembl, May 2017
^"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^Bussemakers MJ, van Bokhoven A, Verhaegh GW, Smit FP, Karthaus HF, Schalken JA, Debruyne FM, Ru N, Isaacs WB (December 1999). "DD3: a new prostate-specific gene, highly overexpressed in prostate cancer". Cancer Research. 59 (23): 5975–9. PMID 10606244.
^Neves AF, Araújo TG, Biase WK, Meola J, Alcântara TM, Freitas DG, Goulart LR (October 2008). "Combined analysis of multiple mRNA markers by RT-PCR assay for prostate cancer diagnosis". Clinical Biochemistry. 41 (14–15): 1191–8. doi:10.1016/j.clinbiochem.2008.06.013. PMID 18640109.
^Loeb S (November 2008). "Does PCA3 help identify clinically significant prostate cancer?". European Urology. 54 (5): 980–1. doi:10.1016/j.eururo.2008.07.027. PMID 18684556.
Prostate cancer antigen 3 (PCA3, also referred to as DD3) is a gene that expresses a non-coding RNA. PCA3 is only expressed in human prostate tissue, and...
score), or urine levels of mRNA molecules common to prostate tumors like PCA3 and TMPRSS2 fused to ERG. Several large studies have found that men screened...
biopsy is needed. Prostate cancer antigen 3 (PCA3) is a urine test that detects the overexpression of the PCA3 gene, an indicator of prostate cancer. ConfirmMDx...
(MALAT1), H19, maternally expressed gene 3 (MEG3), prostate cancer antigen 3 (PCA3), the long intergenic non-coding RNA 00261 (LINC00261), etc. However, as...
to bring to market MyProstateScore, a pre-biopsy test using the T2-ERG, PCA3, and KLK3 biomarkers to detect clinically significant prostate cancer. He...
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