PADI3 information

PADI3
Identifiers
Aliases	PADI3, PAD3, PDI3, peptidyl arginine deiminase 3, UHS1
External IDs	OMIM: 606755; MGI: 1338891; HomoloGene: 7882; GeneCards: PADI3; OMA:PADI3 - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	17,284,233 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	140,537,959 bp
RNA expression pattern
	Top expressed in
	urinary bladder; ; testicle; ; olfactory zone of nasal mucosa; ; vagina; ; tonsil; ; skin of abdomen; ; gallbladder; ; gonad; ; prostate; ; skin of leg;
	Top expressed in
	lip; ; hair follicle; ; skin of back; ; embryo; ; granulocyte; ; skin of abdomen; ; morula; ; transitional epithelium of urinary bladder; ; epiblast; ; Gonadal ridge;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	hydrolase activity; calcium ion binding; identical protein binding; protein-arginine deiminase activity;
Cellular component	cytosol; nucleus; cytoplasm;
Biological process	chromatin organization;
	Sources:Amigo / QuickGO
Orthologs
	51702
	18601
	ENSG00000280549; ENSG00000142619
	ENSMUSG00000025328
	Q9ULW8
	Q9Z184
	NM_016233
	NM_011060
	NP_057317
	NP_035190
	Wikidata
View/Edit Human	View/Edit Mouse

Peptidyl arginine deiminase, type III, also known as PADI3, is a protein which in humans is encoded by the PADI3 gene.^[5]^[6]

This gene encodes a member of the peptidyl arginine deiminase family of enzymes, which catalyze the post-translational deimination of proteins by converting arginine residues into citrullines in the presence of calcium ions. The family members have distinct substrate specificities and tissue-specific expression patterns. The type III enzyme modulates hair structural proteins, such as filaggrin in the hair follicle and trichohyalin in the inner root sheath, during hair follicle formation. Together with the type I enzyme, this enzyme may also play a role in terminal differentiation of the epidermis. This gene exists in a cluster with four other paralogous genes.^[5]

^ ^a ^b ^c ENSG00000142619 GRCh38: Ensembl release 89: ENSG00000280549, ENSG00000142619 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000025328 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ ^a ^b "Entrez Gene: PADI3 peptidyl arginine deiminase, type III".
^ Kanno T, Kawada A, Yamanouchi J, Yosida-Noro C, Yoshiki A, Shiraiwa M, Kusakabe M, Manabe M, Tezuka T, Takahara H (November 2000). "Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin". The Journal of Investigative Dermatology. 115 (5): 813–23. doi:10.1046/j.1523-1747.2000.00131.x. PMID 11069618.

[refGRCh38Ensembl-1] ENSG00000142619 GRCh38: Ensembl release 89: ENSG00000280549, ENSG00000142619 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000025328 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: PADI3 peptidyl arginine deiminase, type III".

[pmid11069618-6] Kanno T, Kawada A, Yamanouchi J, Yosida-Noro C, Yoshiki A, Shiraiwa M, Kusakabe M, Manabe M, Tezuka T, Takahara H (November 2000). "Human peptidylarginine deiminase type III: molecular cloning and nucleotide sequence of the cDNA, properties of the recombinant enzyme, and immunohistochemical localization in human skin". The Journal of Investigative Dermatology. 115 (5): 813–23. doi:10.1046/j.1523-1747.2000.00131.x. PMID 11069618.

PADI3 information

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PADI3

Uncombable hair syndrome

Paspalum dilatatum