P2RX5 information

P2RX5
Identifiers
Aliases	P2RX5, LRH-1, P2X5, P2X5R, purinergic receptor P2X 5
External IDs	OMIM: 602836; MGI: 2137026; HomoloGene: 1924; GeneCards: P2RX5; OMA:P2RX5 - orthologs
Gene location (Human)
Chr.	Chromosome 17 (human)
End	3,696,240 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	73,063,511 bp
RNA expression pattern
	Top expressed in
	spleen; ; lymph node; ; appendix; ; granulocyte; ; mucosa of ileum; ; blood; ; apex of heart; ; gastrocnemius muscle; ; bone marrow cells; ; glutes;
	Top expressed in
	brown adipose tissue; ; soleus muscle; ; masseter muscle; ; facial motor nucleus; ; ascending aorta; ; intercostal muscle; ; myocardium of ventricle; ; motor neuron; ; muscle of thigh; ; proximal tubule;
	More reference expression data
	n/a
Gene ontology
Molecular function	ion channel activity; ATP binding; transmembrane signaling receptor activity; purinergic nucleotide receptor activity; extracellularly ATP-gated cation channel activity; ATP-gated ion channel activity;
Cellular component	integral component of membrane; integral component of nuclear inner membrane; integral component of plasma membrane; membrane; plasma membrane; cytosol; postsynapse;
Biological process	response to ATP; positive regulation of calcium-mediated signaling; ion transport; positive regulation of calcium ion transport into cytosol; cation transmembrane transport; signal transduction; nervous system development; blood coagulation; purinergic nucleotide receptor signaling pathway; excitatory postsynaptic potential; cation transport; ion transmembrane transport;
	Sources:Amigo / QuickGO
Orthologs
	5026
	94045
	ENSG00000083454
	ENSMUSG00000005950
	Q93086
	n/a
	NM_175081; NM_001204519; NM_001204520; NM_002561; NM_175080
	NM_033321; NM_001376982; NM_001376983
	NP_001191448; NP_001191449; NP_002552; NP_778255
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

P2X purinoceptor 5 is a protein that in humans is encoded by the P2RX5 gene.^[5]^[6]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel. Several characteristic motifs of ATP-gated channels are present in its primary structure, but, unlike other members of the purinoceptors family, this receptor has only a single transmembrane domain. Four transcript variants encoding distinct isoforms have been identified for this gene.^[6]

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000083454 – Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000005950 – Ensembl, May 2017
^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
^ Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett. 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125. S2CID 42070561.
^ ^a ^b "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000083454 – Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000005950 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9414125-5] Le KT, Paquet M, Nouel D, Babinski K, Seguela P (Jan 1998). "Primary structure and expression of a naturally truncated human P2X ATP receptor subunit from brain and immune system". FEBS Lett. 418 (1–2): 195–9. doi:10.1016/S0014-5793(97)01380-X. PMID 9414125. S2CID 42070561.

[entrez-6] "Entrez Gene: P2RX5 purinergic receptor P2X, ligand-gated ion channel, 5".

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