Cornell University (B.S.) Stanford University School of Medicine (M.D.)
Scientific career
Institutions
Stanford University MIT University of California, Los Angeles Howard Hughes Medical Institute
Website
www.stemcell.ucla.edu/member/witte
Owen Witte (born May 17, 1949) is an American physician-scientist at the University of California, Los Angeles. He is a University Professor of microbiology, immunology and molecular genetics in the David Geffen School of Medicine at UCLA, founding director emeritus of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, and the UC Regents’ David Saxon Presidential Chair in developmental immunology (1989–present).[1] Witte is also a Howard Hughes Medical Institute investigator (1986–2016) and a member of the President's Cancer Panel (2012 to 2016),[2] the National Academy of Sciences, the National Academy of Medicine, the American Academy of Arts and Sciences, and the Cancer Research Academy of the AACR. He serves on numerous editorial boards and scientific advisory boards for academic centers and biotechnology companies.
Witte should be recognized for multiple seminal contributions over the last 50 years impacting our understanding of human leukemias, immune disorders and epithelial cancers, which have defined new targets for attack that have foreshadowed and strongly influenced the development of new therapies that have changed medical practice and patient outcomes. His discovery of the tyrosine kinase activity in the ABL1 protein[3] and the demonstration of the BCR-ABL oncoproteins in leukemias[4] was one of the preclinical discoveries that led to the development of Gleevec, the first targeted therapy for chronic myelogenous leukemia.[1]
Witte also co-discovered the gene for Bruton's tyrosine kinase,[5] a protein essential for normal B-lymphocyte development that, when mutated, causes the onset of X-linked agammaglobulinemia.[6] This finding stimulated the creation of new targeted therapies like Ibrutinib that have transformed treatment for CLL, B cell lymphomas, multiple myeloma and certain autoimmune diseases.[1]
His current research focuses on characterizing the stem cells for epithelial cancers of the prostate and other organs in order to define new and more targeted therapies.[7][8] Using tissue modeling techniques, Witte discovered the prostate stem cell antigen that is up-regulated in prostate cancer,[9] identified the human prostate stem cell population[10] and determined that the protein N-Myc, which is produced by the gene MYCN, leads to the development of aggressive neuroendocrine prostate cancer tumors.[11] Recent striking observations using a human epithelial tissue recombination/transformation system have shown that prostate and other tissues can be driven to an adenocarcinoma state by defined oncogenic signaling, and further trans-differentiated by epigenetic control to highly aggressive small cell carcinoma with neuroendocrine features — defining new immune targets for therapy under active investigation.
^ abcVogt-James, Mirabai (August 3, 2015). "The 2015 AQACR Clowes Memorial Award for Outstanding Achievement in Basic Cancer Research". Cancer Immunology Research. 3 (8): 846–848. doi:10.1158/2326-6066.CIR-15-0142. PMID 26242762.
^"President's Cancer Panel".
^Witte ON, Dasgupta A, Baltimore D (February 28, 1980). "Abelson murine leukemia virus protein is phosphorylated in vitro to form phosphotyrosine". Nature. 283 (5750): 826–831. Bibcode:1980Natur.283..826W. doi:10.1038/283826a0. PMID 6244493. S2CID 4239008.
^Konopka JB, Watanabe SM, Witte ON (July 1984). "An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity" (PDF). Cell. 37 (3): 1035–42. doi:10.1016/0092-8674(84)90438-0. PMID 6204766. S2CID 34525263.
^Tsukada S; Saffran DC; Rawlings DJ; Parolini O; Allen RC; Klisak I; et al. (January 29, 1993). "Deficient expression of a B-cell cytoplasmic tyrosine kinase in human X-linked agammaglobulinemia". Cell. 72 (2): 279–90. doi:10.1016/0092-8674(93)90667-f. PMID 8425221. S2CID 32339052.
^Rawlings DJ; Scharenberg AM; Park H; Wahl MI; Lin S; Kato RM; et al. (February 9, 1996). "Activation of Btk by a phosphorylation mechanism initiated by src family kinases". Science. 271 (5250): 822–5. Bibcode:1996Sci...271..822R. doi:10.1126/science.271.5250.822. PMID 8629002. S2CID 42666246.
^"SU2C Scientific Research Teams, Owen N. Witte, M.D." Stand Up To Cancer.
^"Owen N. Witte, MD | Class of 2014". American Association for Cancer Research.
^Reiter, R.E.; Gu, Z.; Watabe, T.; Thomas, G.; Szigeti, K.; Davis, E.; Wahl, M.; Nisitani, S.; Yamashiro, J.; Le Beau, M.M.; Loda, M.; Witte, O.N. (February 17, 1998). "Prostate stem cell antigen: A cell surface marker overexpressed in prostate cancer". Proceedings of the National Academy of Sciences. 95 (4): 1735–40. Bibcode:1998PNAS...95.1735R. doi:10.1073/pnas.95.4.1735. PMC 19171. PMID 9465086.
^Goldstein, A.S.; Huang, J.; Guo, C.; Garraway, I.P.; Witte, O.N. (July 30, 2010). "Identification of a cell-of-origin for human prostate cancer". Science. 329 (5991): 568–71. Bibcode:2010Sci...329..568G. doi:10.1126/science.1189992. PMC 2917982. PMID 20671189.
^Lee JK, Phillips JW, Smith BA, Park JW, Stoyanova T, Clark PM, Baertsch R, Sokolov A, Meyerowitz JG, Mathis C, Cheng D, Stuart JM, Gustafson WC, Huang J, Witte ON (April 11, 2016). "N-Myc drives small cell neuroendocrine carcinoma initiated from human prostate epithelial cells". Cancer Cell. 29 (4): 536–547. doi:10.1016/j.ccell.2016.03.001. PMC 4829466. PMID 27050099.
OwenWitte (born May 17, 1949) is an American physician-scientist at the University of California, Los Angeles. He is a University Professor of microbiology...
President of Stanford (1916–1943), personal physician of President Harding OwenWitte – Distinguished Professor and Founding Director of the UCLA Eli and Edythe...
Metastatic Treatment-Resistant Prostate Cancer Led by Eric J. Small, OwenWitte SU2C-PCF Dream Team: Precision Therapy for Advanced Prostate Cancer Led...
next generation of medicine.Under the leadership of founding director OwenWitte and co-director Judith Gasson, the institute began recruiting internationally...
(d.) Shelley E. Taylor Peter K. Vogt Jeffrey A. Whitsett M. Roy Wilson OwenWitte Keith Yamamoto Oded Abramsky Paula Allen-Meares Frances Arnold Francine...
University, Nicholas Lydon, Amgen, Inc., Alex Matter, Novartis Pharma AG, and OwenWitte, University of California, Los Angeles. For Development of Abl kinase...
team ran 3:28.40 in the heats. Time from the heats; De Witte was replaced in the final. "Owen Westerhout snel in spoor van vriendin". Noordhollands Dagblad...
2014 Irving Weissman, MD Stanford University School of Medicine 2014 OwenWitte, MD University of California, Los Angeles 2015 Kenneth C. Anderson, MD...
believed that..." Witte, p. 124 Wortman, p. 311 Witte, p. 94 Harcave, p. 32 Owen, p. 173 Harcave, Sidney (2004). Count Sergei Witte and the twilight of...
evolutionary adaptations to terrestrialization Kees (P. C.) Goudswaard, Frans Witte, Lauren J. Chapman, Decline of the African lungfish (Protopterus aethiopicus)...
at AV Trias. Among the athletes he has trained are Laura de Witte, Lisanne de Witte, Owen Westerhout and Jamile Samuel. Dutch Indoor Athletics Championships...
Dietmar Schönherr, Wolfgang Völz Drama Der Club der grünen Witwen Udo Witte [de] Rita Russek [de], Christine Neubauer, Ursula Karven, Manon Straché [de]...
Destroyer 2,616 23 April 1946 decommissioned 1968, sunk as target 1969 Witte de With Royal Netherlands Navy Admiralen Destroyer 1,316 20 February 1930...
Brooklyn Daily Eagle. p. E9. Retrieved December 12, 2015 – via Newspapers.com. Witte, Lawrence (December 9, 1960). "Static". Denton Journal. p. 10. Retrieved...
the Reptiles of East Africa. Academic Press, London. ISBN 0-12-656470-1. Witte, F.; de Zeeuw, M.P.; Brooks, E. (2016). "Haplochromis nyererei". IUCN Red...
forgettable portion of realpolitik". PCGamesN. Retrieved 27 December 2021. A. DeWitte, Joel (17 November 2020). "Tropico 6 (Switch) Review". Nintendo World Report...
2016. Archived from the original on 1 July 2016. Retrieved 30 June 2016. Witte, Griff (30 June 2016). "Stung by a betrayal, former London mayor Boris Johnson...
study." Newman arrived in New York City in 1951 with his first wife, Jackie Witte, taking up residence in the St. George section of Staten Island. He made...
(2004). Count Sergei Witte and the twilight of imperial Russia: a biography. M.E. Sharpe. ISBN 978-0-7656-1422-3. Thomas C. Owen (2005). Dilemmas of Russian...
announces campaign for Senate in Maryland". CNN. Retrieved September 8, 2023. Witte, Brian (February 9, 2024). "Former Maryland Gov. Larry Hogan is running...
Helpers" James Knox Unknown November 23, 2012 (2012-11-23) Hilma Marie Witte talked her sons, Eric and John, into committing murder. Eric shot his father...
Mainwaring 2003, p. 181. Witte, Craeybeckx & Meynen 2009, p. 119. Sturzo 1939, p. 479. Witte 1993, p. 56-57. Witte 1993, p. 56. Witte 1993, p. 57. Invernizzi...